Early predictors of acute hepatitis B progression to liver failure
| Autor: | Yandan Zhong, Tian Xiong, Hua-Li Wang, Ping Huang, Yongfeng Yang, Qingfang Xiong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
HBsAg Gastroenterology and hepatology Physiology medicine.medical_treatment lcsh:Medicine Aminotransferases Liver transplantation Gastroenterology Biochemistry Hepatitis 0302 clinical medicine Medicine and Health Sciences Medicine Bile 030212 general & internal medicine lcsh:Science Hepatic encephalopathy Pathology and laboratory medicine Multidisciplinary medicine.diagnostic_test digestive oral and skin physiology Hepatitis B Medical microbiology Middle Aged Prognosis Body Fluids Enzymes Infectious hepatitis HBeAg Viruses Acute Disease Disease Progression Infectious diseases 030211 gastroenterology & hepatology Female Pathogens Anatomy Research Article Adult medicine.medical_specialty Hepatitis B virus Adolescent Acute Liver Failure Surgical and Invasive Medical Procedures Viral diseases Microbiology 03 medical and health sciences Digestive System Procedures Young Adult Transferases Internal medicine Humans Liver diseases Aged Retrospective Studies Prothrombin time Transplantation Biology and life sciences business.industry lcsh:R Viral pathogens Organisms Proteins Bilirubin Organ Transplantation medicine.disease Hepatitis viruses Liver Transplantation Microbial pathogens Enzymology lcsh:Q business Liver Failure |
| Zdroj: | PLoS ONE PLoS ONE, Vol 13, Iss 7, p e0201049 (2018) |
| ISSN: | 1932-6203 |
| Popis: | Background and aims 1~4% of acute hepatitis B (AHB) cases in adults progresses to acute liver failure (ALF).The predictors of ALF and prognosis for patients with ALF are not clear. This study investigated some of predictive and prognostic factors for AHB progression to ALF. Methods A retrospective analysis was used to assess the clinical and laboratory features of 293 patients diagnosed with AHB; the patients were divided into the following two groups: ALF (n = 13) and non-ALF (n = 280). Results In total,13 of the 293 (4.43%) patients developed ALF (10 recovered、3 died). The variables of age, anti-HBc IgM titers≥10 S/CO, HBeAg negativity, and total bilirubin (TB) at admission were significantly higher in ALF patients than in non-ALF patients. Compared to non-ALF patients, ALF patients had significantly lower values for prothrombin time activity (PTA), serum albumin, and HBV DNA. At discharge, ALF patients had lower TB normalization rates and much faster clearance of HBsAg, HBeAg and HBVDNA than non-ALF patients. In multivariate analysis, TB≥5×upper limit of normal (ULN) and HBeAg negative status were independent predictors for ALF development at admission, with 84.6% sensitivity, 85.7% specificity, a likelihood ratio of 5.91 and an area under the receiver operating characteristics curve (AUROC) of 0.850.Those who died had lower levels of peak PTA ( |
| Databáze: | OpenAIRE |
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