HLA in familial and nonfamilial Mediterranean Kaposi's sarcoma in Greece
Autor: | John Stratigos, C. Papasteriades, S. Hadjiyannis, Anna Filiotou, J. Economidou, Andreas Kaloterakis |
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Rok vydání: | 1995 |
Předmět: |
Adult
Male Linkage disequilibrium Pathology medicine.medical_specialty Immunology Human leukocyte antigen Biochemistry HLA-DR5 Antigen Pathogenesis Antigen HLA Antigens Genetics Genetic predisposition Immunology and Allergy Medicine Humans Genetic Predisposition to Disease Prospective Studies Kaposi's sarcoma Sarcoma Kaposi Aged Aged 80 and over Greece urogenital system business.industry Incidence Haplotype General Medicine Middle Aged medicine.disease Female Sarcoma Disease Susceptibility business |
Zdroj: | Tissue antigens. 45(2) |
ISSN: | 0001-2815 |
Popis: | Fifty-four (54) unrelated patients with Mediterranean Kaposi's sarcoma (MKS) and 8 patients members of 4 unrelated families with familial MKS were serotyped for HLA-A,B and DR antigens. The diagnosis was histologically confirmed and all patients were negative for anti-HIV antibodies. An increased frequency of HLA-B18 (44.4% vs 14.2% in the controls, p < 0.001, RR = 4.8) and HLA-DR5 (57.6% vs 37.2% in the controls, p < 0.025, RR = 2.29) was observed in the group of patients with MKS. Seven (7) of the 8 family members with FMKS possessed HLA-DR5, and the affected members in the 3 families shared a common haplotype which included HLA-DR5. These findings support the hypothesis that genetic factors linked to HLA-DR5 antigen may contribute to the pathogenesis of MKS. |
Databáze: | OpenAIRE |
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