Acute plasma expansion: left ventricular hemodynamics and endocrine function during exercise
| Autor: | Inge-Lis Kanstrup, P. F. Hoilund-Carlsen, J. Marving |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Cardiac output Sympathetic Nervous System Physiology Plasma Substitutes Blood volume Ventricular Function Left Oxygen Consumption Heart Rate Endocrine Glands Physiology (medical) Internal medicine Heart rate Humans Medicine Cardiac Output Exercise business.industry Central venous pressure Stroke Volume Stroke volume Middle Aged Myocardial Contraction Hormones Preload Endocrinology medicine.anatomical_structure Hemoglobinometry Vascular resistance Cardiology End-diastolic volume Female business |
| Zdroj: | Journal of Applied Physiology. 73:1791-1796 |
| ISSN: | 1522-1601 8750-7587 |
| Popis: | In 11 healthy subjects (8 males and 3 females, age 21–59 yr) left ventricular end-diastolic (LVEDV) and end-systolic (LVESV) volumes were measured in the supine position by isotope cardiography at rest and during two submaximal one-legged exercise loads before and 1 h after acute plasma expansion (PE) by use of a 6% dextran solution (500–750 ml). After PE, blood volume increased from 5.22 +/- 0.92 to 5.71 +/- 1.02 (SD) liters (P < 0.01). At rest, cardiac output increased 30% (5.3 +/- 1.0 to 6.9 +/- 1.6 l/min; P < 0.01), stroke volume increased from 90 +/- 20 to 100 +/- 28 ml (P < 0.05), and LVEDV increased from 134 +/- 29 to 142 +/- 40 ml (NS). LVESV was unchanged (44 +/- 11 and 42 +/- 14 ml). Heart rate rose from 60 +/- 7 to 71 +/- 10 beats/min (P < 0.01). The cardiac preload [central venous pressure (CVP)] was insignificantly elevated (4.9 +/- 2.1 and 5.3 +/- 3.0 mmHg); systemic vascular resistance and arterial pressures were significantly reduced (mean pressure fell from 91 +/- 11 to 85 +/- 11 mmHg, P < 0.01). Left ventricular peak filling and peak ejection rates both increased (19 and 14%, respectively; P < 0.05). During exercise, cardiac output remained elevated after PE compared with the control situation, predominantly due to a 10- to 14-ml rise in stroke volume caused by an increased LVEDV, whereas LVESV was unchanged. CVP increased after PE by 2.1 and 3.0 mmHg, respectively (P < 0.05).2+ remained unchanged during exercise compared with rest after PE in |
| Databáze: | OpenAIRE |
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