Liver metastasis at diagnosis in children with nephroblastoma enrolled in SIOP2001 protocol: A French multicentric study

Autor: Isabelle Pellier, Jean Michon, Hélène Sudour-Bonnange, Hervé Brisse, Sabine Irtan, Arnauld Verschuur, Virginie Languillat-Fouquet, Sabine Sarnacki, Anne Notz-Carrere, Magali Morelle, Christophe Bergeron, Cécile Boulanger, Frédérique Dijoud, Claire Freycon, Estelle Thebaud, Marie-Dominique Tabone, Aurore Coulomb-L'Hermine, Antoine Liné, Georges Audry, Claudia Pasqualini
Přispěvatelé: Institut Curie [Paris], Service de neurochirurgie pédiatrique [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance Publique - Hôpitaux de Marseille (APHM), CHU Necker - Enfants Malades [AP-HP], Centre hospitalier universitaire de Nantes (CHU Nantes), Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne (GATE Lyon Saint-Étienne), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), CCA - Cancer Treatment and Quality of Life, Assistance Publique-Hôpitaux de Marseille (AP-HM), Groupe d'analyse et de théorie économique (GATE Lyon Saint-Étienne), Centre National de la Recherche Scientifique (CNRS)-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
tumors
medicine.medical_treatment
Nephrectomy
Gastroenterology
Metastasis
Liver disease
0302 clinical medicine
Prospective Studies
Child
ComputingMilieux_MISCELLANEOUS
Liver Neoplasms
Remission Induction
Wilms tumor
Hematology
pediatric oncology
solid tumors
[SHS.ECO]Humanities and Social Sciences/Economics and Finance
Primary tumor
Kidney Neoplasms
3. Good health
Survival Rate
Treatment Outcome
Oncology
Child
Preschool
030220 oncology & carcinogenesis
Female
medicine.symptom
Metastasectomy
medicine.medical_specialty
03 medical and health sciences
Internal medicine
medicine
Hepatectomy
Humans
Anaplasia
Retrospective Studies
clinical trials
business.industry
Infant
Wilms' tumor
medicine.disease
Radiation therapy
liver metastasis
Pediatrics
Perinatology and Child Health
renal tumor
business
Follow-Up Studies
030215 immunology
Zdroj: Pediatric Blood and Cancer
Pediatric Blood and Cancer, 2020, 67 (6), ⟨10.1002/pbc.28201⟩
Pediatric blood & cancer, 67(6):e28201. Wiley-Liss Inc.
Pediatric Blood and Cancer, Wiley, 2020, 67 (6), ⟨10.1002/pbc.28201⟩
ISSN: 1545-5009
1545-5017
DOI: 10.1002/pbc.28201⟩
Popis: Background Liver metastases are rare in children with Wilms tumor (WT), and their impact on the outcome is unclear. Patients and methods The French cohort of patients with WT presenting liver metastases at diagnosis and enrolled in the International Society of Pediatric Oncology (SIOP) 2001 study was reviewed. Results From 2002 to 2012, 906 French patients were enrolled in the SIOP2001 trial. Among them, 131 (14%) presented with stage IV WT and 18 (1.9%) had liver metastases at diagnosis. Isolated liver metastases were displayed in four of them. After preoperative chemotherapy, persistent liver disease was reported in 14/18 patients, and 13 of them underwent metastasectomy after nephrectomy. In resected liver lesions, the same histology of the primary tumor was reported for three patients, blastemal cells without anaplasia were identified in one patient with DA-WT, and post-chemotherapy necrosis/fibrosis was identified for the other 10 patients. For the four patients who had liver and lung surgery, both sites had nonviable cells with post-chemotherapy necrosis/fibrosis. Six patients had hepatic radiotherapy. Sixteen patients achieved primary complete remission and were alive at the last follow-up (median follow-up: 6.4 years). The only two deceased patients presented diffuse anaplasia histology. The five-year EFS and OS were 83% (60%-94%) and 88% (66%-97%), respectively. Conclusion Liver involvement does not appear to be an adverse prognostic factor in metastatic WT. The role of hepatic surgery and radiotherapy remains unclear, and should be carefully considered in case of persistent liver metastases, according to histology and radiological response to other metastatic sites.
Databáze: OpenAIRE
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