Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival
| Autor: | Thomas Winkler, Julia Rolf, John F. Kearney, Elisabeth Georges-Labouesse, Zerina Lokmic, Jian Song, Xueli Zhang, Markus A. Rüegg, Arnoud Sonnenberg, Nathalie Horn, Melanie Jane Hannocks, Chuan Wu, Tim Lämmermann, Susanna Cardell, Rupert Hallmann, Lydia Sorokin |
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| Rok vydání: | 2013 |
| Předmět: |
Stromal cell
Cell Survival T cell Population Integrin Biology Extracellular matrix Mice 03 medical and health sciences 0302 clinical medicine Bone Marrow Cell Movement Laminin medicine Animals Agrin education B cell 030304 developmental biology Mice Knockout B-Lymphocytes 0303 health sciences education.field_of_study Multidisciplinary Integrin alpha6beta1 Marginal zone Extracellular Matrix Cell biology medicine.anatomical_structure PNAS Plus Immunology biology.protein Spleen 030217 neurology & neurosurgery |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America |
| DOI: | 10.5451/unibas-ep29038 |
| Popis: | We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin α5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with reduced laminin α5 expression show reduced MZ B cells and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow, without changes in other immune or stromal cell compartments. Transient integrin α6β1-mediated interaction of NF B cells with laminin α5 in the MZ supports the MZ B-cell population, their long-term survival, and antibody response. Data suggest that the unique 3D structure and biochemical composition of the ECM of lymphoid organs impacts on immune cell fate. |
| Databáze: | OpenAIRE |
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