Race, Ancestry, and Development of Food-Allergen Sensitization in Early Childhood
| Autor: | Xiaobin Wang, Howard Bauchner, Melanie Fu, X. Hong, Xin Liu, Katherin Ortiz, Colleen Pearson, Jacqueline A. Pongracic, Rajesh Kumar, Hui Ju Tsai, Guoying Wang |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Gerontology Multivariate analysis Genotype medicine.disease_cause White People Cohort Studies Allergen Food allergy Humans Medicine Sensitization business.industry Urban Health Infant Health Status Disparities Hispanic or Latino Articles Odds ratio Immunoglobulin E medicine.disease Confidence interval Black or African American Logistic Models medicine.anatomical_structure Child Preschool Multivariate Analysis Pediatrics Perinatology and Child Health Cohort Female Self Report business Food Hypersensitivity Demography Cohort study |
| Zdroj: | Pediatrics. 128:e821-e829 |
| ISSN: | 1098-4275 0031-4005 |
| DOI: | 10.1542/peds.2011-0691 |
| Popis: | OBJECTIVE: We examined whether the risk of food-allergen sensitization varied according to self-identified race or genetic ancestry. METHODS: We studied 1104 children (mean age: 2.7 years) from an urban multiethnic birth cohort. Food sensitization was defined as specific immunoglobulin E (sIgE) levels of ≥0.35 kilo–units of allergen (kUA)/L for any of 8 common food allergens. Multivariate logistic regression analyses were used to evaluate the associations of self-identified race and genetic ancestry with food sensitization. Analyses also examined associations with numbers of food sensitizations (0, 1 or 2, and ≥3 foods) and with logarithmically transformed allergen sIgE levels. RESULTS: In this predominantly minority cohort (60.9% black and 22.5% Hispanic), 35.5% of subjects exhibited food sensitizations. In multivariate models, both self-reported black race (odds ratio [OR]: 2.34 [95% confidence interval [CI]: 1.24–4.44]) and African ancestry (in 10% increments; OR: 1.07 [95% CI: 1.02–1.14]) were associated with food sensitization. Self-reported black race (OR: 3.76 [95% CI: 1.09–12.97]) and African ancestry (OR: 1.19 [95% CI: 1.07–1.32]) were associated with a high number (≥3) of food sensitizations. African ancestry was associated with increased odds of peanut sIgE levels of ≥5 kUA/L (OR: 1.25 [95% CI: 1.01–1.52]). Similar ancestry associations were seen for egg sIgE levels of ≥2 kUA/L (OR: 1.13 [95% CI: 1.01–1.27]) and milk sIgE levels of ≥5 kUA/L (OR: 1.24 [95% CI: 0.94–1.63]), although findings were not significant for milk. CONCLUSIONS: Black children were more likely to be sensitized to food allergens and were sensitized to more foods. African ancestry was associated with peanut sensitization. |
| Databáze: | OpenAIRE |
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