Diverse functionalization of strong alkyl C–H bonds by undirected borylation

Autor:	Sam He, Isaac Yu, Erik A. Romero, Raphael J. Oeschger, Christian Ehinger, John F. Hartwig, Bo Su
Rok vydání:	2020
Předmět:	chemistry.chemical_classification Multidisciplinary chemistry.chemical_element Substrate (chemistry) Chemical synthesis Borylation Article Catalysis Solvent chemistry Polymer chemistry Iridium Selectivity Alkyl
Zdroj:	Science
ISSN:	1095-9203 0036-8075
DOI:	10.1126/science.aba6146
Popis:	Speeding up borylation Catalytic borylation is the rare reaction that can selectively target stronger over weaker saturated carbon–hydrogen (C–H) bonds. However, the trade-off has been that the reaction is slow and requires high excess of the hydrocarbon. Oeschger et al. now report that the right ligand (2-methylphenanthroline) coordinated to iridium can accelerate the reaction by 50- to 80-fold. This rate enhancement enables selective borylation of primary C–H bonds with the hydrocarbon as limiting reagent. The reaction is also unusually selective for β-C–H bonds in saturated heterocycles. Science , this issue p. 736
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327cd6560fcfb198f0d3c571c25513b8 https://doi.org/10.1126/science.aba6146 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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