Relationship between circulating IGF-1 levels and traumatic brain injury-induced hippocampal damage and cognitive dysfunction in immature rats
| Autor: | Ayfer Dayi, Ilkay Aksu, Ferihan Cetin, M. Nuri Arda, Basak Baykara, Tugba Gurpinar, Durgul Ozdemir, Ali Riza Sisman, Nazan Uysal, Muge Kiray |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Traumatic brain injury Statistics as Topic Morris water navigation task Hippocampus Hippocampal formation Cresyl violet chemistry.chemical_compound Cognition Internal medicine medicine Animals Insulin-Like Growth Factor I Rats Wistar TUNEL assay General Neuroscience medicine.disease Rats Endocrinology Traumatic injury chemistry Brain Injuries Psychology Cognition Disorders Neuroscience |
| Popis: | It is well known that traumatic brain injury (TBI) induces the cognitive dysfunction resulting from hippocampal damage. In the present study, we aimed to assess whether the circulating IGF-I levels are associated with cognition and hippocampal damage in 7-day-old rat pups subjected to contusion injury. Hippocampal damage was examined by cresyl violet staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Spatial memory performance was assessed in the Morris water maze. Serum IGF-1 levels decreased in both early and late period of TBI. Decreased levels of serum IGF-1 were correlated with hippocampal neuron loss and spatial memory deficits. Circulating IGF-1 levels may be predictive of cognitive dysfunction resulted from hippocampal damage following traumatic injury in developing brain. Therapy strategies that increase circulating IGF-1 may be highly promising for preventing the unfavorable outcomes of traumatic damage in young children. (C) 2011 Elsevier Ireland Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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