Low-dose famotidine and ranitidine as single post-prandial doses: a three-period placebo-controlled comparative trial
| Autor: | S. G. Mann, L. Stauffer, R. P. Walt, T. G. Reilly, Shalendra Singh, J. Cottrell |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Pharmacology Ranitidine Placebo Histamine H2 receptor Oral administration medicine Humans Pharmacology (medical) Analysis of Variance Cross-Over Studies Hepatology business.industry Gastroenterology Hydrogen-Ion Concentration Anti-Ulcer Agents Famotidine Postprandial Period Elixir Crossover study Postprandial Histamine H2 Antagonists Calibration Female business medicine.drug |
| Zdroj: | Alimentary Pharmacology & Therapeutics. 10:749-755 |
| ISSN: | 0269-2813 |
| Popis: | Background : Low-dose H 2 -receptor antagonists are available without prescription for the self-medication of dyspepsia. Methods : To investigate the relative abilities of low doses of famotidine and ranitidine to raise intragastric pH after a single post-prandial evening dose, 25 healthy volunteers completed a three-period cross-over trial of famotidine 10 mg, ranitidine elixir 75 mg and placebo. A standard meal was given at 18.30 h and drug or placebo at 19.30 h to subjects fasted for 5.5 h. Intragastric pH was recorded with nasogastric electrodes from 18.00 to 07.30 h by GastrograpH II recorder. Results : The geometric mean area under the pH-time curve for the 5-9 h post-dose period was 1.49 pH units/h following placebo, 3.43 pH units/h following famotidine 10 mg (agent/placebo ratio 2.3 ; P < 0.001, ANOVA) and 2.6 pH units/h following ranitidine 75 mg (1.75 ; P < 0.001). The geometric mean area under the pH-time curve ratio of famotidine 10 mg to ranitidine 75 mg was 1.32 (P < 0.016). Median pH over the 5-9 h period was 1.1 following placebo, 2.7 following famotidine 10 mg (P < 0.05 by comparison with placebo) and 1.9 following ranitidine 75 mg (P < 0.05) ; comparison of median pH showed no significant difference between the active drugs. The percentage of pH values greater than 3.0 for the period 0-12 h post-dose was 9.7% following placebo, 30.0% following famotidine 10 mg (P < 0.05) and 24.9% following ranitidine 75 mg (P < 0.05) ; there was no significant difference between the active drugs. Conclusions : We conclude that both famotidine 10 mg and ranitidine 75 mg significantly raise intragastric pH when given as single post-prandial doses. Famotidine 10 mg may have a greater effect than ranitidine elixir 75 mg over the 5-9-h period after dosing. |
| Databáze: | OpenAIRE |
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