Prognostic Importance of C-KIT Mutations in Core Binding Factor Acute Myeloid Leukemia: A Systematic Review
| Autor: | Mohammad Hadi Sadeghian, Masumeh Ghazanfarpour, Hossein Ayatollahi, Ehsan Yazdandoust, Maryam Sheikhi, Seyyede Fatemeh Shams, Arezoo Shajiei, Sepideh Shakeri |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Poor prognosis Databases Factual inv(16) medicine.disease_cause Bioinformatics lcsh:RC254-282 Translocation Genetic 03 medical and health sciences 0302 clinical medicine CBF-AML Internal medicine White blood cell hemic and lymphatic diseases medicine Humans Core binding factor acute myeloid leukemia t(8 21) Mutation business.industry lcsh:RC633-647.5 Myeloid leukemia General Medicine lcsh:Diseases of the blood and blood-forming organs Hematology medicine.disease Prognosis lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Survival Rate Leukemia Leukemia Myeloid Acute Proto-Oncogene Proteins c-kit 030104 developmental biology medicine.anatomical_structure c-kit 030220 oncology & carcinogenesis Chromosome Inversion Bone marrow business Leukemic Blasts |
| Zdroj: | Hematology/Oncology and Stem Cell Therapy, Vol 10, Iss 1, Pp 1-7 (2017) |
| ISSN: | 1658-3876 |
| DOI: | 10.1016/j.hemonc.2016.08.005 |
| Popis: | Objective/background: Acute myeloid leukemia (AML) is defined as leukemic blast reproduction in bone marrow. Chromosomal abnormalities form different subgroups with joint clinical specifications and results. t(8;21)(q22;q22) and inv(16)(p13;q22) form core binding factor-AML (CBF-AML). c-kit mutation activation occurs in 12.8–46.1% of adults with CBF leukemia. These mutations occur in 20–25% of t(8;21) and 30% of inv(16) cases. Methods: In this systematic review, we searched different databases, including PubMed, Scopus, and Embase. Selected articles were measured based on the inclusion criteria of this study and initially compared in terms of titles or abstracts. Finally, articles relevant to the subject of this review were retrieved in full text. Twenty-two articles matched the inclusion criteria and were selected for this review. Results: In this study, c-kit mutations were associated with poor prognosis in AML patients with t(8;21) and inv(16). In addition, these mutations had better prognostic effects on AML patients with inv(16) compared with those with t(8;21). Conclusion: According to the results of this study, c-kit mutations have intense, harmful effects on the relapse and white blood cell increase in CBF-AML adults. However, these mutations have no significant prognostic effects on patients. Keywords: CBF-AML, c-kit, t(8;21), inv(16) |
| Databáze: | OpenAIRE |
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