Potential Increased Risk of Trisomy 18 Observed After a Fertilizer Warehouse Fire in Brazos County and TX
| Autor: | Yau Adamu, Xiaohui Xu, JeongWon Han, Xiao Zhang, Bangning Zhang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Health
Toxicology and Mutagenesis lcsh:Medicine 010501 environmental sciences engineering.material 01 natural sciences Article 03 medical and health sciences Pregnancy medicine Humans chromosomal anomalies Fertilizers 030304 developmental biology 0105 earth and related environmental sciences trisomy 0303 health sciences business.industry lcsh:R Significant difference Public Health Environmental and Occupational Health fertilizer medicine.disease Texas Confidence interval Fire accident birth defects Increased risk engineering Female Observational study Fertilizer Trisomy business Trisomy 18 Syndrome fire Demography |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 17, Iss 2561, p 2561 (2020) International Journal of Environmental Research and Public Health Volume 17 Issue 7 |
| ISSN: | 1660-4601 |
| Popis: | Background: In this paper, we aimed to investigate the potential impacts of a fire accident in a fertilizer warehouse on chromosomal anomalies, including Trisomy 21 (T21) and Trisomy (T18) among pregnancies in Brazos County, Texas. We conducted an observational study in Brazos County, TX, with all patients of T18 and T21 cases in the live births in Brazos County between 2005&ndash 2014. The prevalence of T18 and T21 before, during, and after the accident in Brazos County were calculated and compared. The Standardized Morbidity Ratio (SMR) was applied to compare the prevalence of T18 and T21 in Brazos County to the statewide prevalence in Texas after adjusting for maternal race and age. Compared with statewide risk, the risk of T18 during the impacted years in Brazos county was found to be significantly higher (SMR = 5.0, 95% Confidence Interval(CI): 2.19&ndash 9.89), while there was no significant difference before (SMR = 0.77, 0.13&ndash 2.54) and after the accident (SMR = 0.71, 0.12&ndash 2.36). However, the prevalence of T21 during the impacted years was not significantly different from those before or after the accident. This study conclusively suggests that this fertilizer fire may be related to the increased prevalence of T18 in Brazos County, though the findings warrant further investigation. |
| Databáze: | OpenAIRE |
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