Population-Based Pediatric Hospitalization Burden of Lineage-Specific Influenza B in Hong Kong, 2004–2014
| Autor: | J S Malik Peiris, Peng Wu, Janice Y.C. Lo, Kwok-Hung Chan, Benjamin J. Cowling, Eunice L.Y. Chan, Lok-Yee So, Susan S. Chiu, Vicky J. Fang |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Male Pediatrics medicine.medical_specialty Lineage (genetic) Adolescent 030106 microbiology Context (language use) Disease Real-Time Polymerase Chain Reaction Virus 03 medical and health sciences Lineage specific 0302 clinical medicine Cost of Illness Nasopharynx Influenza Human Major Article Medicine Humans 030212 general & internal medicine Typing Child Disease burden business.industry Influenzavirus B Infant Hospitalization Influenza B virus Infectious Diseases Child Preschool Epidemiological Monitoring Hong Kong Female sense organs business |
| Popis: | Background Influenza B virus has been perceived to cause less disease burden and milder disease compared with influenza A, but recent studies suggest that influenza B does have a significant impact. We aimed to estimate the burden of influenza B virus infections on hospitalizations in Hong Kong, in the context of virus lineage changes over time. Methods The pediatric age-specific rates of influenza B hospitalization in Hong Kong for 2004-2014 were estimated based on admissions to 2 hospitals that together catered for 72.5% of all pediatric admissions on Hong Kong Island. Influenza B virus was detected by immunofluorescence and culture on nasopharyngeal aspirates. Lineage typing was performed by real-time reverse-transcription polymerase chain reaction. Results A total of 5085 children were recruited on 1 designated day each week, year-round during the 11 years, and 221 (4.3%) tested positive for influenza B. Hospitalization rates were highest in children aged 2 to |
| Databáze: | OpenAIRE |
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