Glycated haemoglobin levels among 3295 hospitalized COVID-19 patients, with and without diabetes, and risk of severe infection, admission to an intensive care unit and all-cause mortality
| Autor: | Emil L. Fosbøl, Ulrik M. Mogensen, Christian Torp-Pedersen, Amna Alhakak, Jannik Langtved Pallisgaard, Lars Køber, Jawad H. Butt, Thomas A. Gerds, Peter Weeke, Gunnar Gislason, Johanna Krøll |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
medicine.medical_specialty endocrine system diseases Coronavirus disease 2019 (COVID-19) Endocrinology Diabetes and Metabolism law.invention Hba1c level Endocrinology law cardiovascular disease Internal medicine Diabetes mellitus Internal Medicine Medicine Humans Glycated haemoglobin Aged Glycated Hemoglobin antidiabetic drug database research population study business.industry SARS-CoV-2 Absolute risk reduction COVID-19 Original Articles medicine.disease Intensive care unit Intensive Care Units glycaemic control Diabetes Mellitus Type 2 Population study Original Article Female business All cause mortality hypoglycaemia |
| Zdroj: | Alhakak, A, Butt, J H, Gerds, T A, Fosbol, E L, Mogensen, U M, Kroll, J, Pallisgaard, J L, Gislason, G H, Torp-Pedersen, C, Kober, L & Weeke, P E 2022, ' Glycated haemoglobin levels among 3295 hospitalized COVID-19 patients, with and without diabetes, and risk of severe infection, admission to an intensive care unit and all-cause mortality ', Diabetes, Obesity and Metabolism, vol. 24, no. 3, pp. 499-510 . https://doi.org/10.1111/dom.14604 Alhakak, A, Butt, J H, Gerds, T A, Fosbøl, E L, Mogensen, U M, Krøll, J, Pallisgaard, J, Gislason, G H, Torp-Pedersen, C, Køber, L & Weeke, P E 2022, ' Glycated haemoglobin levels among 3295 hospitalized COVID-19 patients, with and without diabetes, and risk of severe infection, admission to an intensive care unit and all-cause mortality ', Diabetes, Obesity and Metabolism, vol. 24, no. 3, pp. 499-510 . https://doi.org/10.1111/dom.14604 Diabetes, Obesity & Metabolism Alhakak, A, Butt, J H, Gerds, T A, Fosbøl, E L, Mogensen, U M, Krøll, J, Pallisgaard, J L, Gislason, G H, Torp-Pedersen, C, Køber, L & Weeke, P E 2022, ' Glycated haemoglobin levels among 3295 hospitalized COVID-19 patients, with and without diabetes, and risk of severe infection, admission to an intensive care unit and all-cause mortality ', Diabetes, Obesity and Metabolism, vol. 24, no. 3, pp. 499-510 . https://doi.org/10.1111/dom.14604 |
| Popis: | AimTo determine the risk of adverse outcomes across the spectrum of glycated haemoglobin (HbA1c) levels among hospitalized COVID-19 patients with and without diabetes.Materials and methodsDanish nationwide registries were used to study the association between HbA1c levels and 30-day risk of all-cause mortality and the composite of severe COVID-19 infection, intensive care unit (ICU) admission and all-cause mortality. The study population comprised patients hospitalized with COVID-19 (3 March 2020 to 31 December 2020) with a positive polymerase chain reaction (PCR) test and an available HbA1c ≤ 6 months before the first positive PCR test. All patients had at least 30 days of follow-up. Among patients with diabetes, HbA1c was categorized as 64 mmol/mol. Among patients without diabetes, HbA1c was stratified into ResultsWe identified 3295 hospitalized COVID-19 patients with an available HbA1c (56.2% male, median age 73.9 years), of whom 35.8% had diabetes. The median HbA1c was 54 and 37 mmol/mol among patients with and without diabetes, respectively. Among patients with diabetes, the standardized absolute risk difference of the composite outcome was higher with HbA1c 64 mmol/mol (15.1% [95% CI 6.2% to 24.0%]), compared with HbA1c 59 to 64 mmol/mol (reference). Among patients without diabetes, the standardized absolute risk difference of the composite outcome was greater with HbA1c ConclusionsPatients with COVID-19 and HbA1c 64 mmol/mol had a higher associated risk of the composite outcome. Similarly, among patients without diabetes, varying HbA1c levels were associated with higher risk of the composite outcome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|