Genesis of Non-Coding RNA Genes in Human Chromosome 22—A Sequence Connection with Protein Genes Separated by Evolutionary Time
| Autor: | Nicholas Delihas |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
lcsh:QH426-470
de novo gene birth Pseudogene pseudogenes Biology Biochemistry Genome Conserved sequence 03 medical and health sciences Exon 0302 clinical medicine Alu sequences Genetics long noncoding RNA genes Molecular Biology Gene 030304 developmental biology Segmental duplication 0303 health sciences protogene Non-coding RNA lcsh:Genetics USP18 Perspective gene evolution GGT5 Human genome 030217 neurology & neurosurgery |
| Zdroj: | Non-Coding RNA Non-Coding RNA, Vol 6, Iss 36, p 36 (2020) |
| ISSN: | 2311-553X |
| DOI: | 10.3390/ncrna6030036 |
| Popis: | A small phylogenetically conserved sequence of 11,231 bp, termed FAM247, is repeated in human chromosome 22 by segmental duplications. This sequence forms part of diverse genes that span evolutionary time, the protein genes being the earliest as they are present in zebrafish and/or mice genomes, and the long noncoding RNA genes and pseudogenes the most recent as they appear to be present only in the human genome. We propose that the conserved sequence provides a nucleation site for new gene development at evolutionarily conserved chromosomal loci where the FAM247 sequences reside. The FAM247 sequence also carries information in its open reading frames that provides protein exon amino acid sequences; one exon plays an integral role in immune system regulation, specifically, the function of ubiquitin-specific protease (USP18) in the regulation of interferon. An analysis of this multifaceted sequence and the genesis of genes that contain it is presented. |
| Databáze: | OpenAIRE |
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