Ultrastructural aspects of pseudoxanthoma elasticum
| Autor: | Luciana Boff de Abreu, Valéria Magalhães Jorge, Mariana Geber de Almeida, Hiram Larangeira de Almeida |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Scanning electron microscope Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dermis Microscopy medicine Humans Pseudoxanthoma Elasticum Orcein Aged Skin Staining and Labeling Chemistry Elastic tissue Microscopy electron scanning Anatomy Pseudoxanthoma elasticum medicine.disease Spine Staining Microscopy electron transmission Dermatopathology 030104 developmental biology medicine.anatomical_structure Transmission electron microscopy RL1-803 Ultrastructure Female Collagen |
| Zdroj: | Anais Brasileiros de Dermatologia, Vol 92, Iss 4, Pp 527-530 (2017) Anais Brasileiros de Dermatologia, Volume: 92, Issue: 4, Pages: 527-530, Published: AUG 2017 Anais Brasileiros de Dermatologia v.92 n.4 2017 Anais brasileiros de dermatologia Sociedade Brasileira de Dermatologia (SBD) instacron:SBD Anais Brasileiros de Dermatologia |
| ISSN: | 0365-0596 |
| Popis: | We report the ultrastructural findings in a case of a 72-year-old black woman with confluent yellowish papules in the cervical region. She had no comorbidities. Ophthalmological examination, electrocardiogram, and echocardiogram were normal. Hematoxylin-eosin staining of the affected skin showed strong alterations in the mid-dermis with irregular clumps of eosinophilic material and loss of the normal parallel arrangement of collagen bundles. Orcein staining revealed that the elastic fibers lost their normal linear configuration, showing clump fragmentation, sometimes forming square structures. Transmission electron microscopy showed aberrant elastic fibers with an irregular outline and heterogenic inner structures. We also observed small elastic fibers. Collagen fibers showed a normal structure with irregular distribution. Scanning electron microscopy revealed important disorganization of collagen fibers and small stone-like deposits measuring around 5 µm associated with bigger structures ranging from 10-16 µm. Higher magnification revealed that these small stone-like structures were sometimes polyhedral-shaped or squared. |
| Databáze: | OpenAIRE |
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