Extracellular Vesicles Derived from Chimeric Antigen Receptor-T Cells: A Potential Therapy for Cancer
| Autor: | Tova Waks, Maya Levin, Galit Horn, Einav Zagagi Yohay, Naamit Deshet Unger, Anat Amit Aharon, Irit Avivi, Tali Hana Bar-Lev, Anat Levin |
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| Rok vydání: | 2021 |
| Předmět: |
Receptors
Chimeric Antigen Chemistry Genetically engineered T-Lymphocytes medicine.medical_treatment Cancer therapy Cancer Immunotherapy medicine.disease Immunotherapy Adoptive Extracellular vesicles Chimeric antigen receptor Extracellular Vesicles Antigen Neoplasms Genetics medicine Cancer research Humans Molecular Medicine Car t cells human activities Molecular Biology |
| Zdroj: | Human Gene Therapy. 32:1224-1241 |
| ISSN: | 1557-7422 1043-0342 |
| Popis: | Chimeric antigen receptor (CAR)-T cells are genetically engineered T cells, directed against a tumor-associated antigen. Extracellular vesicles (EVs) derived from CAR-T cells (CAR-T EVs) may preserve CAR-T activity and overcome one of the major obstacles responsible for CAR-T cell failure in patients with solid tumors. This study aimed to compare CAR-T EVs with their parental cells and explore their cell penetration and cytotoxic activity. Anti-HER-2 CARs were stimulated with specific target cells. EVs were isolated from the cell media and characterized for their content and functions. We found that CAR-T EVs contained a mixture of small and large EVs. Stimulated anti-HER-2 |
| Databáze: | OpenAIRE |
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