The Entorhinal Cortex Atrophy Score Is Diagnostic and Prognostic in Mild Cognitive Impairment
| Autor: | Michael T. Heneka, Catherine N. Widmann, Andreas Traschütz, Nenad Polomac, Elke Hattingen, S Jonas Enkirch, Hans H. Schild |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Neuropsychological Tests Verbal learning 03 medical and health sciences 0302 clinical medicine Atrophy Internal medicine mental disorders medicine Dementia Entorhinal Cortex Humans Cognitive Dysfunction ddc:610 Cognitive decline Aged Retrospective Studies Cerebral atrophy Aged 80 and over business.industry General Neuroscience Neuropsychology General Medicine Middle Aged medicine.disease Entorhinal cortex Prognosis Magnetic Resonance Imaging Psychiatry and Mental health Clinical Psychology 030104 developmental biology Cardiology Disease Progression Biomarker (medicine) Female Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's disease 75(1), 99-108 (2020). doi:10.3233/JAD-181150 |
| ISSN: | 1875-8908 |
| Popis: | Background Structural magnetic resonance imaging (MRI) is routinely performed in patients with mild cognitive impairment (MCI), but diagnostic accuracy to detect early cerebral atrophy is limited. Objective To validate the visual entorhinal cortex atrophy (ERICA) rating scale regarding diagnosis, biomarker status, neuropsychological profile, and dementia risk in MCI. Methods The ERICA score was retrospectively assessed regarding its discrimination of MCI (n = 80) from subjective cognitive decline and Alzheimer's disease (AD) dementia (n = 60, respectively), its prediction of conversion to dementia (median follow-up 28 months) and amyloid/tau biomarker status, and its association with neuropsychological tests. Results The ERICA score achieved 97% positive predictive value (PPV) for the presence of MCI. Discrimination between MCI and AD dementia (area under the curve: 0.71) was comparable to volumetry, and superior to the medial temporal lobe atrophy (MTA) score (p = 0.006). The PPV of the ERICA score for conversion to dementia was 83%, equivalent to tau status. It achieved 90% PPV for conversion when combined with tau, and 100% negative predictive value with verbal recall. While no measure predicted the predominantly positive amyloid status, the ERICA score was at least comparable to volumetry, and superior to the MTA score in predicting tau positivity (92% PPV for phospho-tau). The ERICA score was associated with verbal learning and memory, and, unlike the MTA score, also with AD-specific deficits in cued verbal recall. Conclusion The ERICA score is a simple and valuable tool to exploit structural MRI for diagnosis and prognosis in MCI and is non-inferior to volumetry. |
| Databáze: | OpenAIRE |
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