Natriuretic peptide resistance of mesenteric arteries in spontaneous hypertensive rat is alleviated by exercise

Autor: Chang P, Zhang B, Su Xl, Zhao G, Jun Yu, Zhang Xc, Wang Jb, Tie R, Haifeng Zhang, Bao-Ying Chen, Miao-Zhang Zhu
Rok vydání: 2015
Předmět:
0301 basic medicine
medicine.medical_specialty
Physiology
Sildenafil
medicine.drug_class
Drug Resistance
Vasodilation
Blood Pressure
030204 cardiovascular system & hematology
Rats
Inbred WKY
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Atrial natriuretic peptide
Internal medicine
Physical Conditioning
Animal
Rats
Inbred SHR
medicine
Natriuretic peptide
Animals
Spontaneous hypertensive rat
Mesenteric arteries
Dose-Response Relationship
Drug
business.industry
General Medicine
Mesenteric Arteries
Rats
030104 developmental biology
medicine.anatomical_structure
Blood pressure
Endocrinology
chemistry
cGMP-specific phosphodiesterase type 5
Hypertension
cardiovascular system
business
hormones
hormone substitutes
and hormone antagonists
Atrial Natriuretic Factor
circulatory and respiratory physiology
Zdroj: Physiological research. 65(2)
ISSN: 1802-9973
Popis: Proximal resistance vessels, such as the mesenteric arteries, contribute substantially to the peripheral resistance. The reactivity of resistance vessels to vasoactive substance like natriuretic peptides plays an important role in the regulation of blood pressure. In current study, we investigated the reactivity of mesenteric arteries to atrial natriuretic peptide (ANP), a well known vasodilating factor, in spontaneously hypertensive rats (SHR), as well as the effects of exercise training on it. As a result, ANP-induced vasorelaxation was attenuated in SHR with significantly increased phosphodiesterase type 5 (PDE5), and decreased cGMP/ANP ratio, compared with WKY rats as control. Intriguingly, the decreased reactivity to ANP in SHR was markedly reversed by exercise training. In addition, ANP resistance of in vitro mesenteric arteries was diminished by sildenafil a potent selective inhibitor of PDE5. In conclusion, ANP resistance occurs in resistance vessels of SHR, suggesting predisposition to hypertension, which can be reversed by exercise.
Databáze: OpenAIRE
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