Carmeda surface heparinization in neonatal ECMO systems: long-term experiments in a sheep model
| Autor: | R. Benz, Björn Frenckner, H. Ehrén, Kenneth Palmer |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
0301 basic medicine
Activated clotting time Hemorrhage 030204 cardiovascular system & hematology 03 medical and health sciences Extracorporeal Membrane Oxygenation 0302 clinical medicine medicine Animals Radiology Nuclear Medicine and imaging Advanced and Specialized Nursing Sheep medicine.diagnostic_test Heparin business.industry Hemoglobin A Thrombosis General Medicine Fibrin Monomer Heparin coating 030104 developmental biology Hematocrit Anesthesia Cardiology and Cardiovascular Medicine business Safety Research medicine.drug |
| Zdroj: | Perfusion. 10:307-313 |
| ISSN: | 1477-111X 0267-6591 |
| DOI: | 10.1177/026765919501000505 |
| Popis: | The thromboresistance in three Carmeda (Stockholm, Sweden) heparin- coated neonatal ECMO systems with a runtime of 45, 56 and 96 hours, respectively, and three noncoated systems with a runtime of 12, 42 and 66 hours, respectively, were compared using a sheep model. The flow rate was 200 ml/min and the activated clotting time (ACT) was kept at approximately 120 seconds. At the end of the experiment, the heparin-coated systems only contained minimal clotting while the controls showed major clotting in the entire system. Fibrin monomers were not detected until after 24 hours in the heparin- coated group, but demonstrated within 60 minutes in the noncoated group. It is concluded that the Carmeda heparin coating has a thromboresistant effect, and may be used to reduce the need for systemic heparinization in ECMO treatment of neonates. |
| Databáze: | OpenAIRE |
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