Anti-cyclic citrullinated peptide antibodies in lung diseases associated with rheumatoid arthritis
| Autor: | Takafumi Suda, Noriyuki Enomoto, Naoki Inui, Yasunori Kageyama, Hiroshi Watanabe, Kingo Chida |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male musculoskeletal diseases Clinical Biochemistry Arthritis Peptides Cyclic Arthritis Rheumatoid immune system diseases medicine Humans skin and connective tissue diseases Aged Autoantibodies Retrospective Studies Lung biology business.industry Interstitial lung disease Follicular bronchiolitis Retrospective cohort study General Medicine Middle Aged medicine.disease medicine.anatomical_structure Bronchiolitis Rheumatoid arthritis Immunology biology.protein Female Antibody Lung Diseases Interstitial business |
| Zdroj: | Clinical Biochemistry. 41:1074-1077 |
| ISSN: | 0009-9120 |
| DOI: | 10.1016/j.clinbiochem.2008.06.014 |
| Popis: | Objective Anti-cyclic citrullinated peptide (anti-CCP) antibodies are highly specific markers for rheumatoid arthritis (RA) and useful for predicting RA development and progression. However, it has not been fully determined whether anti-CCP antibodies are associated with pulmonary diseases in RA patients. In the present study, we aimed to elucidate the relationships between anti-CCP antibodies and pulmonary diseases, particularly interstitial lung disease (ILD) and bronchiolitis. Design and methods Using an enzyme-linked immunosorbent assay, the presence of serum anti-CCP antibodies was examined in 18 RA patients with ILD and bronchiolitis who were diagnosed based on pathologic findings. A further 36 RA subjects without any pulmonary diseases served as a reference population. Results No significant differences were found for the prevalences and levels of anti-CCP antibodies between patients with and without ILD and follicular bronchiolitis. Conclusion Detection of serum anti-CCP antibodies has no association with pulmonary diseases in RA patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect