Three Synchronous Primary Extranodal Mantle Cell Lymphomas Involving Torus Tubarius, Posterior Nasopharynx, and Base of the Tongue 65 Years After Treatment of Chronic Sinusitis with Nasopharyngeal Radium Irradiation
Autor: | Yan Fang, Robert E. Pollard, Ahmed Ali Khalid, Tomislav M. Jelic, Oscar C Estalilla, Andrew M. Plata |
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Rok vydání: | 2019 |
Předmět: |
Male
Pathology medicine.medical_specialty Neoplasms Radiation-Induced Brachytherapy Nasopharyngeal neoplasm chemistry.chemical_element Lymphoma Mantle-Cell 030204 cardiovascular system & hematology Ionizing radiation Radium Neoplasms Multiple Primary 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases medicine Humans Sinusitis Aged 80 and over business.industry Eustachian Tube Chronic sinusitis Cancer Nasopharyngeal Neoplasms General Medicine Articles medicine.disease Lymphoma Tongue Neoplasms medicine.anatomical_structure chemistry Torus tubarius 030220 oncology & carcinogenesis Chronic Disease Mantle cell lymphoma business |
Zdroj: | The American Journal of Case Reports |
ISSN: | 1941-5923 |
Popis: | Patient: Male, 81 Final Diagnosis: Mantle cell lymphoma Symptoms: Dificulty in swallowing and pain in the right ear Medication: — Clinical Procedure: Otorhinolaryngology panendoscopy • biopsy of the tumors Specialty: Otolaryngology Objective: Rare disease Background: Radiation, specifically ionizing radiation, causes broad-spectrum gene damage, including double-strand DNA breaks, single DNA strand breaks, cross links, and individual base lesions, thus causing chromosomal translocations, deletions, point mutations, and, consequently, various types of cancer. Radiation also causes genomic instability in cells, which enhances the rate of mutations in the descendants of the irradiated cell after many generations of normal replications. Case Report: We report the first case of mantle cell lymphoma of the torus tubarius, and the first CD10-positive mantle cell lymphoma of the Waldeyer’s ring. Mantle cell lymphoma appeared 65 years after treatment of chronic sinusitis with nasopharyngeal radium irradiation. Conclusions: On the basis of the medical literature about atomic bomb survivors, nuclear plant workers, and radiologists exposed to radiation, and our case, we conclude that radiation can, in a very small percentage of exposed individuals, cause non-Hodgkin lymphoma: in 0.24% of atomic bomb survivors and in at least 0.13% of the patients treated with nasopharyngeal radium irradiation. Non-Hodgkin lymphoma can occur many decades after radiation exposure, and individuals treated with nasopharyngeal radium irradiation, usually in their childhood, need continuing follow-up. |
Databáze: | OpenAIRE |
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