Oxidative stress is important in the pathogenesis of stress‑related mucosal disease
| Autor: | Xiu-Li Zuo, Haipeng Yuan, Xiaohong Wang, Xiaopei Li, Qin Zhao, Dongfang Bai, Huanling Shi, Na Shi, Feng Qi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
malondialdehyde
0301 basic medicine Cancer Research medicine.medical_specialty H&E stain medicine.disease_cause Gastroenterology Nitric oxide Pathogenesis Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immunology and Microbiology (miscellaneous) Internal medicine medicine Gastric mucosa oxidative stress biology business.industry inducible NO synthase Albumin Articles General Medicine Malondialdehyde stress-related mucosal disease Acute Physiology and Chronic Health Evaluation II score 030104 developmental biology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis biology.protein business Oxidative stress |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| DOI: | 10.3892/etm.2020.9211 |
| Popis: | Stress-related mucosal disease (SRMD) is a common complication in patients in the intensive care unit (ICU). The aim of the present study was to investigate the possible mechanisms for the pathogenesis of SRMD. In total, 38 patients with SRMD were enrolled from an ICU, as well as 15 healthy volunteers. The disease severity of patients in ICU was evaluated using the Acute Physiology and Chronic Health Evaluation (APACHE) II score. Gastric mucosa with the most severe lesions were biopsied for hematoxylin and eosin staining and then assessed by pathological damage scoring. The serum levels of malondialdehyde (MDA), superoxide dismutase (SOD) and ischemic modified albumin (IMA) were also detected. In addition, claudin-3 and inducible nitric oxide (NO) synthase (iNOS) in the gastric mucosa were assessed by western blotting and immunohistochemistry. The average APACHE II score of the patients with SRMD was significantly higher compared with the controls. Moreover, the levels of MDA (4.74±2.89 nmol/ml) and IMA (93.61±10.78 U/ml) in patients with SRMD were significantly higher compared with the controls (P |
| Databáze: | OpenAIRE |
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