Oligopeptides of Three to Five Residues Derived from Uveitopathogenic Sites of Retinal S-Antigen Induce Experimental Autoimmune Uveitis (EAU) in Lewis Rats
| Autor: | Toshimichi Shinohara, Kotaro Eto, Vijay K. Singh, Santhanakrishinan Sunil |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Lymphocyte
Molecular Sequence Data Immunology Peptide Biology Lymphocyte Activation Autoimmune Diseases Uveitis chemistry.chemical_compound medicine Animals Amino Acid Sequence Antigens Eye Proteins Autoimmune disease chemistry.chemical_classification Oligopeptide Arrestin Cell growth Immunogenicity Retinal medicine.disease Peptide Fragments Rats Disease Models Animal medicine.anatomical_structure chemistry Biochemistry Rats Inbred Lew biology.protein Female Vitronectin Lymph Nodes Oligopeptides |
| Zdroj: | Cellular Immunology. 148:198-207 |
| ISSN: | 0008-8749 |
| DOI: | 10.1006/cimm.1993.1102 |
| Popis: | We have previously reported that microbial peptides having 3 to 6 amino acid sequence homology with uveitopathogenic peptide of retinal S-antigen (S-Ag) are capable of inducing experimental autoimmune uveitis (EAU) in Lewis rats and subhuman primates. T-cells obtained from animals immunized with these microbial peptides proliferate when stimulated with S-Ag peptide in culture and vice versa. We were interested to know whether these 3 to 6 identical amino acid residues by themselves were sufficient to induce EAU in susceptible animals under optimal conditions. For this purpose we have determined the response of synthetic oligopeptides of 3 to 18 amino acid residues for their ability to indice EAU. Here, we report that small synthetic oligopeptides of 3 to 5 amino acid residues of the two uveitopathogenic peptides of S-Ag induced EAU in Lewis rats, although with a higher dose (2000 micrograms/rat) than that of the larger peptides (50 micrograms/rat). These results define the core sequences in the uveitopathogenic peptides of retinal S-Ag. |
| Databáze: | OpenAIRE |
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