Tc-99m GSA scintigraphy within the first 3 days after admission as an early predictor of outcome in severe acute liver injury
| Autor: | Hiroaki Abe, Tokio Sasaki, Ryouichi Mikami, Yuji Suzuki, Takuro Sato, Yasuhiro Takikawa, Keisuke Kakisaka |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Science Liver transplantation Scintigraphy Gastroenterology Article Hepatitis 03 medical and health sciences 0302 clinical medicine Liver Function Tests Internal medicine medicine Hepatectomy Humans Radionuclide Imaging Technetium Tc 99m Aggregated Albumin Hepatic encephalopathy Liver diseases Aged Acute liver injury Multidisciplinary medicine.diagnostic_test Receiver operating characteristic business.industry Area under the curve Liver Failure Acute Middle Aged Prognosis medicine.disease Liver Transplantation Liver Hepatic Encephalopathy 030220 oncology & carcinogenesis Technetium Tc 99m Pentetate Medicine 030211 gastroenterology & hepatology Tc-99m-GSA Radiopharmaceuticals business |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Patients with severe acute liver injury (SLI) usually recover spontaneously. However, some SLI patients progress to acute liver failure with varying degrees of hepatic encephalopathy. Acute liver failure is associated with high mortality and can be substantially reduced by liver transplantation. Therefore, distinguishing SLI patients who might progress to acute liver failure and are at a risk of death is important when evaluating patients needing liver transplantation. The present study aimed to determine whether technetium-99m-diethylenetriaminepentaacetic acid galactosyl human serum albumin (Tc-99m GSA) scintigraphy can predict the prognosis of patients with SLI. This prospective observational study included 69 SLI patients. The accuracy of Tc-99m GSA for predicting death or liver transplantation for 6 months was assessed. Between the two groups of patients stratified based on the cut-off values from the receiver operating characteristic curves, 6-month transplant-free survival was compared. Sixteen (23.2%) patients died or underwent liver transplantation from admission (poor outcome). The hepatic accumulation index was calculated by dividing the radioactivity of the liver region of interest by that of the liver-plus-heart region of interest at 15 min (i.e., LHL15). The LHL15 in the 16 patients (0.686) was significantly lower than that in survivors (0.836; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|