Proton beam radiotherapy for uveal melanoma: Results of Curie Institut–Orsay Proton Therapy Center (ICPO)
| Autor: | Hamid Mammar, Eric Frau, François D'Hermies, S. Delacroix, Corine Plancher, Pierre Schlienger, Loïc Feuvret, Jean Jacques Mazeron, Livia Lumbroso-Le Rouic, Georges Noël, Bernard Asselain, Christine Levy, Catherine Nauraye, Paul Garcia, Anne Meyer, Alejandro Mazal, Laurence Desjardins, Rémi Dendale |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Uveal Neoplasms Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Enucleation Disease-Free Survival Eye Enucleation Proton Therapy medicine Humans Radiology Nuclear Medicine and imaging Melanoma Survival rate Proton therapy Aged Retrospective Studies Aged 80 and over Analysis of Variance Radiation business.industry Proportional hazards model Dose fractionation Retrospective cohort study Middle Aged medicine.disease Surgery Survival Rate Radiation therapy Oncology Female Dose Fractionation Radiation Neoplasm Recurrence Local Nuclear medicine business |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 65:780-787 |
| ISSN: | 0360-3016 |
| Popis: | This study reports the results of proton beam radiotherapy based on a retrospective series of patients treated for uveal melanoma at the Orsay Center.Between September 1991 and September 2001, 1,406 patients with uveal melanoma were treated by proton beam radiotherapy. A total dose of 60 cobalt Gray equivalent (CGE) was delivered in 4 fractions on 4 days. Survival rates were determined using Kaplan-Meier estimates. Prognostic factors were determined by multivariate analysis using the Cox model.The median follow-up was 73 months (range, 24-142 months). The 5-year overall survival and metastasis-free survival rates were 79% and 80.6%, respectively. The 5-year local control rate was 96%. The 5-year enucleation for complications rate was 7.7%. Independent prognostic factors for overall survival were age (p0.0001), gender (p0.0003), tumor site (p0.0001), tumor thickness (p = 0.02), tumor diameter (p0.0001), and retinal area receiving at least 30 CGE (p = 0.003). Independent prognostic factors for metastasis-free survival were age (p = 0.0042), retinal detachment (p = 0.01), tumor site (p0.0001), tumor volume (p0.0001), local recurrence (p0.0001), and retinal area receiving at least 30 CGE (p = 0.002). Independent prognostic factors for local control were tumor diameter (p = 0.003) and macular area receiving at least 30 CGE (p = 0.01). Independent prognostic factors for enucleation for complications were tumor thickness (p0.0001) and lens volume receiving at least 30 CGE (p = 0.0002).This retrospective study confirms that proton beam radiotherapy ensures an excellent local control rate. Further clinical studies are required to decrease the incidence of postirradiation ocular complications. |
| Databáze: | OpenAIRE |
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