Can we detect the development of baroreflex sensitivity in humans between 11 and 20 years of age?
| Autor: | Zuzana Nováková, Eva Závodná, Hana Hrstková, Bohumil Fišer, Nataša Honzíková, Miroslav Jíra, Jiri MoudrJ. Moudr |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Physiology Blood Pressure 030204 cardiovascular system & hematology Baroreflex Fingers 03 medical and health sciences 0302 clinical medicine Age Distribution Heart Rate Physiology (medical) Internal medicine medicine Humans Spectral analysis Child Czech Republic Pharmacology Physics fungi Age Factors Models Cardiovascular General Medicine Surgery Cardiology Regression Analysis Female 030217 neurology & neurosurgery |
| Zdroj: | Canadian journal of physiology and pharmacology. 84(12) |
| ISSN: | 0008-4212 |
| Popis: | The aim of the study was to determine changes of baroreflex sensitivity in humans between 11 and 20 years of age. Continuous 5 min blood pressure recordings using a Finapres were taken in 415 healthy subjects while in a sitting, resting position (breathing at a frequency of 0.33 Hz). Beat-by-beat values of interbeat intervals (IBI) or heart rate, and systolic and diastolic blood pressures were measured. Baroreflex sensitivity in ms/mmHg (BRS) and in mHz/mmHg (BRSf) was determined at an average frequency of 0.1 Hz by spectral analysis. BRS did not correlate with age, but BRSf significantly decreased with age (p < 0.001). BRS correlated with mean IBI (p < 0.001) in all subjects and also in the particular subgroups, but BRSf was IBI-independent. Results of multiregression equations were BRS = 1.37 – 0.56 × age (years) + 0.02 × IBI (ms) (p < 0.001 for BRS vs. age and for BRS vs. IBI); BRSf = 34.74 – 0.97 × age (years) – 0.001 × IBI (ms) (p < 0.001 only for BRS vs. age), where age was measured in years and IBI was measured in ms. The limits of BRS were estimated for the total group: 5th percentile, 3.9; 50th percentile, 9.1; and 95th percentile, 18.7 ms/mmHg; and limits for BRSf were 5th percentile, 8.5; 50th percentile, 16.4; and 95th percentile, 33.6 mHz/mmHg. We conclude that IBI-dependent BRS was unchanged in the particular age groups, but the standardization of BRS on IBI decreased with age. BRSf was IBI-independent and better reflected the development of the BRS. |
| Databáze: | OpenAIRE |
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