Neonatal Onset Intestinal Failure: An Italian Multicenter Study
| Autor: | Gennaro, Salvia, Alfredo, Guarino, Terrin, Gianluca, Concetta, Cascioli, Roberto, Paludetto, Flavia, Indrio, Laura, Lega, Silvia, Fanaro, Mauro, Stronati, Luigi, Corvaglia, Paolo, Tagliabue, DE CURTIS, Mario, Pediatric Gastroenterology Hepatology Working Group On Neonatal Gastroenterology Of The Italian Society, O. F., Nutrition |
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| Přispěvatelé: | Salvia, G, Guarino, Alfredo, Terrin, G, Cascioli, C, Paludetto, Roberto, Indrio, F, Lega, L, Fanaro, S, Stronati, M, Corvaglia, L, Tagliabue, P, De Curtis, M, Working Group on Neonatal Gastroenterology of the Italian Society of Pediatric Gastroenterology, Hepatology, N., N. u. t. r. i. t. i. o. |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
Risk Short Bowel Syndrome Pediatrics medicine.medical_specialty Parenteral Nutrition Neonatal intensive care unit Time Factors Population Neonatal onset Neonatal age Models Biological neonate intestinal failure medicine Humans education Retrospective Studies education.field_of_study business.industry Meconium peritonitis Infant Newborn Infant medicine.disease Transplantation Intestinal Diseases Parenteral nutrition Treatment Outcome Italy Pediatrics Perinatology and Child Health Necrotizing enterocolitis Intensive Care Neonatal Female business |
| Popis: | Objective To describe the natural course of intestinal failure with onset in the neonatal period to provide data regarding the occurrence and to provide a population-based survey regarding the spectrum of underlying diseases. Study design We performed a retrospective chart review including infants admitted to the neonatal intensive care unit of 7 Italian tertiary care centers. Intestinal failure was defined as a primary intestinal disease that induces the need of total parenteral nutrition (PN) for more than 4 weeks or the need of partial PN for more than 3 months. Results The total number of live births during the study time within the enrolled institutions was 30 353, and the number of newborns admitted to the neonatal intensive care unit was 5088. Twenty-six patients satisfied the definition of intestinal failure; thus the occurrence rate of intestinal failure was 0.1% among live-birth newborns and 0.5% among infants at high risk. The main underlying diseases leading to intestinal failure in neonatal age were congenital intestinal defects (42.3%), necrotizing enterocolitis (30.8%), severe intestinal motility disorder (11.5%), intestinal obstruction (7.7%), structural enterocyte defects (3.8%), and meconium peritonitis (3.8%). After a follow-up of 36 months, 84.6% of patients achieved intestinal competence, 1 patient was still receiving home PN, 1 patient underwent transplantation, and 2 patients died. Cholestatic liver disease was diagnosed in 54% of observed children. Conclusion An understanding of the incidence, causes, and natural history of intestinal failure would be helpful to appropriately allocate resources and to plan clinical trials. |
| Databáze: | OpenAIRE |
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