By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice
| Autor: | Huawei Zhang, Jianrong Wang, Lei He, Kan Chen, Yingqun Zhou, Yujing Xia, Huerxidan Abudumijiti, Wenxia Lu, Jingjing Li, Ling Xu, Zheng Zhou, Yuqing Zhou, Qin Yin, Weiqi Dai, Jie Lu, Yuanyuan Zheng, Fan Wang, Rongxia Chen, Chengfen Wang, Rong Zhu, Jing Yang, Li Zhou, Chuanyong Guo, Tong Liu, Rong Zhang, Sainan Li |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Carcinoma Hepatocellular Cell Mice Nude Cell Growth Processes resveratrol Resveratrol Mice Random Allocation chemistry.chemical_compound Cell Line Tumor Hexokinase Stilbenes medicine Animals Humans Glycolysis neoplasms Mice Inbred BALB C Traditional medicine business.industry Cell growth Liver Neoplasms apoptosis hepatocellular carcinoma Hep G2 Cells hexokinase 2 Aerobiosis digestive system diseases medicine.anatomical_structure Oncology chemistry Anaerobic glycolysis Apoptosis Cancer cell Cancer research business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | Cancer cells exhibit an altered metabolic phenotype known as the aerobic glycolysis. The expression of HK2 changes the metabolic phenotype of cells to support cancerous growth. In the present study, we investigated the inhibitory effect of resveratrol on HK2 expression and hepatocellular carcinoma (HCC) cell glycolysis. Aerobic glycolysis was observed in four HCC cell lines compared to the normal hepatic cells. Resveratrol sensitized aerobic glycolytic HCC cells to apoptosis, and this effect was attenuated by glycolytic inhibitors. The induction of mitochondrial apoptosis was associated with the decrease of HK2 expression by resveratrol in HCC cells. In addition, resveratrol enhanced sorafenib induced cell growth inhibition in aerobic glycolytic HCC cells. Combination treatment with both reagents inhibited the growth and promoted apoptosis of HCC-bearing mice. The reduction of HK2 by resveratrol provides a new dimension to clinical HCC therapies aimed at preventing disease progression. |
| Databáze: | OpenAIRE |
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