Liver transplantation for post-COVID-19 sclerosing cholangitis
| Autor: | Angela Lee, M.B. Majella Doyle, Alexander N Wein, William C. Chapman |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Abdominal pain medicine.medical_specialty medicine.medical_treatment Cholangitis Sclerosing Case Report Liver transplantation Gastroenterology Liver disease COVID-19 Testing Internal medicine medicine Living Donors Humans Respiratory system business.industry Bile duct SARS-CoV-2 COVID-19 General Medicine Jaundice Middle Aged medicine.disease Liver Transplantation Transplantation Pneumonia medicine.anatomical_structure medicine.symptom business transplantation |
| Zdroj: | BMJ Case Reports |
| ISSN: | 1757-790X |
| Popis: | Since identified in December 2019, COVID-19 has remained a pandemic across the globe. Although primarily a respiratory illness, the impact of COVID-19 on other end organs has been increasingly identified. The effect of COVID-19 on the liver has yet to be completely understood. We describe a case of COVID-19 leading to end-stage cholangiopathy and deceased donor liver transplantation (LT). A 64-year-old man with no underlying respiratory or liver disease presented with acute respiratory distress secondary to COVID-19 pneumonia requiring intubation. Several months after resolution of his respiratory symptoms, he developed transaminitis, worsening jaundice, abdominal pain and dark-coloured urine. Hepatic function remained severely impaired warranting LT 259 days following his initial COVID-19 diagnosis. Explant pathology demonstrated diffuse hepatic injury, onion skinning of the bile ducts and bile duct loss in scattered portal tracts. As more patients develop COVID-19-related complications, we suggest LT as an option for COVID-19-related end-stage liver disease. |
| Databáze: | OpenAIRE |
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