Mini review: Personalization of the radiation therapy management of prostate cancer using MRI-based radiomics
| Autor: | Michelle Leech, Sarah O.S. Osman, Suneil Jain, Laure Marignol |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Male Cancer Research medicine.medical_specialty medicine.medical_treatment Population Personalization Mini review Management of prostate cancer 03 medical and health sciences Prostate cancer 0302 clinical medicine Radiomics Internal medicine Image Interpretation Computer-Assisted medicine Humans Precision Medicine education education.field_of_study business.industry Prostate Prostatic Neoplasms Guideline medicine.disease Magnetic Resonance Imaging Radiation therapy 030104 developmental biology 030220 oncology & carcinogenesis business |
| Zdroj: | Cancer letters. 498 |
| ISSN: | 1872-7980 |
| Popis: | Decisions on how to treat prostate cancer with radiation therapy are guideline-based but as such guidelines have been developed for populations of patients, this invariably leads to overly aggressive treatment in some patients and insufficient treatment in others. Heterogeneity within prostate tumors and in metastatic sites, even within the same patient, is believed to be a major cause of treatment failure. Radiomics biomarkers, more commonly referred to as radiomics 'features", provide readily available, cost-effective, non-invasive tools for screening, detecting tumors and serial monitoring of patients, including assessments of response to therapy and identification of therapeutic complications. Radiomics offers the potential to analyse whole tumors in 3D, as well as sub-regions or 'habitats' within tumors. Combining quantitative information from imaging with pathology, demographic details and other biomarkers will pave the way for personalised treatment selection and monitoring in prostate cancer. The aim of this review is to consider if MRI-based radiomics can bridge the gap between population-based management and personalised management of prostate cancer. |
| Databáze: | OpenAIRE |
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