A hCG-secreting testicular seminoma revealed by male infertility: mechanism of hCG-evoked endocrine disturbances
| Autor: | H. Lefebvre, J. M. Cleret, Annie Laquerrière, J. M. Kuhn |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty medicine.drug_class Urology urologic and male genital diseases Chorionic Gonadotropin Male infertility Human chorionic gonadotropin Endocrinology Testicular Neoplasms Internal medicine medicine Endocrine system Humans Testosterone Hyperplasia Estradiol urogenital system business.industry Leydig Cells General Medicine Seminoma Oligospermia Luteinizing Hormone medicine.disease Gonadotropin Follicle Stimulating Hormone business hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Andrologia. 25(5) |
| ISSN: | 0303-4569 |
| Popis: | Summary. We report a case of a hCG-produc- ing testicular seminoma revealed by a male infer- tility due to oligozoospermia. No palpable tumour was found at clinical examination and the diag- nosis was established on hormonal data and the echography of the testis. The endocrine patterns associated high levels of p-hCG and 17p-oestra- diol contrasting with low levels of LH and FSH and normal levels of testosterone. Immuno- histochemical studies confirmed the ectopic pro- duction of hCG. Histological findings and the evolution of hormonal parameters suggested that hyperoestradiolaemia was probably the conse- quence of a hCG-evoked Leydig cells hyperplasia involving a paracrine mechanism. In fact, after removal of the tumour, a dramatic decrease of plasma sex steroid levels was observed before recovery of normal testicular endocrine and exo- crine functions. Introduction Seminoma is the most frequent testicular neo- plasm in man. Presenting symptoms are usually referable to the tumour mass and/or metastatic diffusion (Hainsworth & Greco, 1983). Whereas seminoma does not arise from testicular endocrine cells, an abnormal secretion of human chorionic gonadotropin (hCG) is observed in 10-26% of cases in which plasma p-hCG can be used as |
| Databáze: | OpenAIRE |
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