Effect of Combined Antimicrobial Therapy on Ischemia/Reperfusion Myocardial Injury in Rats with Acute Inflammation of the Large Intestine against the Background of Alimentary Obesity
| Autor: | E. S. Protsak, O. V. Borshcheva, V Y Borshchev, Michael M. Galagudza, S. M. Minasian, I Y Burovenko, Yury Yu. Borshchev |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Ischemia Myocardial Reperfusion Injury Inflammation Gastroenterology General Biochemistry Genetics and Molecular Biology Proinflammatory cytokine Random Allocation 03 medical and health sciences 0302 clinical medicine Anti-Infective Agents Clarithromycin Internal medicine Animals Medicine Large intestine Intestine Large Obesity cardiovascular diseases Rats Wistar Tumor Necrosis Factor-alpha business.industry Myocardium Body Weight Interleukin-8 General Medicine Amoxicillin Alkaline Phosphatase Antimicrobial medicine.disease Rats Lactobacillus Metronidazole 030104 developmental biology medicine.anatomical_structure Bifidobacterium medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 168:309-312 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | We studied the effect of combined antimicrobial therapy with amoxicillin, metronidazole, and clarithromycin on the severity of ischemia/reperfusion myocardial injury in Wistar rats with alimentary obesity and acute inflammation of the large intestine. General ischemia/reperfusion was reproduced on Langendorff-perfused isolated hearts and infarct size was estimated. Acute inflammation of the large intestine was accompanied by an increase in the blood levels of proinflammatory cytokines. The presence of obesity and acute inflammation of the large intestine did not significantly affect the infarct size in comparison with the control. Administration of antimicrobial drugs to animals with obesity and acute inflammation of the large intestine led to a significant increase in the infarct size, which should be considered when prescribing antimicrobial therapy to patients with comorbidity. |
| Databáze: | OpenAIRE |
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