Impact of Thyroid Hormone Administration on Fluid Requirements and Hepatic Injury Markers in Hemorrhagic Shock Due to Liver Trauma
| Autor: | Anastasios I. Mylonas, Vassilios Smyrniotis, Chryssoula Staikou, Kassiani Theodoraki, Eirini P. Stergiou, Nikolaos Orfanos, Iosifina Karmaniolou, Georgia Kostopanagiotou, Nikolaos Arkadopoulos, Constantinos Pantos |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Mean arterial pressure medicine.medical_specialty Resuscitation Swine Hemodynamics Shock Hemorrhagic Hydroxyethyl Starch Derivatives medicine Animals Acid-Base Equilibrium Triiodothyronine business.industry Thyroid Crystalloid Solutions Surgery medicine.anatomical_structure Liver Anesthesia Shock (circulatory) Hemorrhagic shock Fluid Therapy Isotonic Solutions medicine.symptom business Hormone |
| Zdroj: | Journal of Investigative Surgery. 26:305-311 |
| ISSN: | 1521-0553 0894-1939 |
| Popis: | The aim of the present study was to evaluate the effect of triiodothyronine (T3) administration in a porcine model of hemorrhagic shock due to liver surgery, in terms of hemodynamic stability, acid-base status, and hepatic injury markers.Hemorrhagic shock was induced in swine by left lobe liver resection and allowed bleeding to a mean arterial pressure of 35-40 mmHg for 40 min. Animals were randomly assigned into a sham group (n = 5), a fluid-resuscitated group (n = 7), and a fluid plus T3-resuscitated group (n = 7). T3 was given by continuous intravenous infusion from the beginning of the experiment. After the 40 min of shock animals were resuscitated with the aim of restoring mean arterial pressure (±10% from baseline). Resuscitation lasted for 1 hr and then swine were followed for another 460 min (total 6 hr). Blood loss, hamodynamic parameters, fluids administered, acid-base status, and liver enzymes were measured.Blood loss was similar in both groups. Animals treated with T3 required less fluids than swine resuscitated with crystalloids and colloids only (N/S 0.9%: 1071 ± 189 ml vs. 2429 ± 535 ml, Voluven 6%: 550 ± 96 ml vs. 1000 ± 289 ml, p.05), plus they were less acidotic at the end of the observing period (7.38 ± 0.08 vs. 7.26 ± 0.12, p.05). Tachycardia was not associated with T3 administration. Hepatic enzymes did not exhibit differences between groups.Our study demonstrates the beneficial impact of T3 administration during controlled hemorrhagic shock and resuscitation. Animals resuscitated with T3 necessitate less amounts of fluids to maintain hemodynamic stability and acid-base status. Moreover, T3 administration does not seem to aggravate blood loss or harm the hepatic tissue. |
| Databáze: | OpenAIRE |
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