Acute Generalized Exanthematous Pustulosis in an African American Male Caused by Trimethoprim-Sulfamethoxazole
| Autor: | Moshe Y. Bressler, Jeremy Minkowitz, Rebecca Tamez, Andrew Mekaiel, Naeha Pathak |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Dermatology 030204 cardiovascular system & hematology trimethoprim-sulfamethoxazole Allergy/Immunology 03 medical and health sciences drug-induced hypersensitivity 0302 clinical medicine Pathology medicine Genetic predisposition bactrim tmp-smx predictive genetic testing Autoimmune disease Sterile pustules African american business.industry agep Sulfamethoxazole human leukocyte antigen (hla) General Engineering medicine.disease Acute generalized exanthematous pustulosis Trimethoprim immune system Drug induced hypersensitivity business 030217 neurology & neurosurgery african american medicine.drug |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| DOI: | 10.7759/cureus.9591 |
| Popis: | Acute generalized exanthematous pustulosis (AGEP) is a rare drug-induced autoimmune disease that presents with hundreds of sterile pustules and systemic symptoms. Genetic predisposition, race, and medications prescribed are all factors in AGEP’s frequency, which occurs most commonly in Caucasians and with the use of macrolides and aminopenicillins. Cases of AGEP with sulfonamides or in African American patients are rare. To our knowledge, this is the first documented example of trimethoprim-sulfamethoxazole-induced AGEP in an African American male. In this article, we will further discuss our case and review the literature. |
| Databáze: | OpenAIRE |
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