Contrast Dose-to-Creatinine Clearance Ratio as a Potential Indicator of Risk for Radiocontrast-Induced Nephropathy
| Autor: | Joseph A Pierro, Judith A Johnson, Richard Cambron, Paul Sherwin |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Pathology
medicine.medical_specialty Metabolic Clearance Rate media_common.quotation_subject Urology Contrast Media Renal function Nephropathy Correlation Risk Factors Triiodobenzoic Acids medicine Contrast (vision) Radiology Nuclear Medicine and imaging Contrast dose Least-Squares Analysis Radiocontrast induced nephropathy Chromatography High Pressure Liquid media_common Dose-Response Relationship Drug Chemistry General Medicine Acute Kidney Injury medicine.disease Iodixanol Dose–response relationship Area Under Curve Creatinine medicine.drug |
| Zdroj: | Investigative Radiology. 40:598-603 |
| ISSN: | 0020-9996 |
| DOI: | 10.1097/01.rli.0000174476.62724.82 |
| Popis: | Objectives Identification of risk factors is important for preventing radiocontrast-induced nephropathy (RCIN). Contrast dose and renal function have been shown in most but not all studies to be risk factors for RCIN. We are investigating the ratio of contrast dose to creatinine clearance (D/CrCL) as a risk indicator. Theory shows that the D/CrCL ratio equals the area under the concentration-time curve (AUC), an accepted measure of systemic exposure. This study investigated the correlation between calculated D/CrCL and experimentally measured AUC for the contrast agent iodixanol. Materials and methods Experimental data on AUC from a phase 1 study of iodixanol were plotted against the D/CrCL ratio and the degree of correlation was determined. Results Experimentally determined AUC data correlate highly with the D/CrCL ratio. Conclusions The D/CrCL ratio is a rapid and accurate way to estimate AUC for an iodinated x-ray contrast agent without the need for multiple blood samples. |
| Databáze: | OpenAIRE |
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