Efficacy of human Lyme disease vaccine formulations in a mouse model
| Autor: | F. S. Kantor, Richard A. Flavell, Andrew Spielman, Stephen W. Barthold, Y. Lobet, Erol Fikrig, Sam R. Telford |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Lipoproteins Recombinant Fusion Proteins Aluminum Hydroxide Spirochaetaceae Microbiology law.invention Mice Lyme disease Ticks Adjuvants Immunologic Borrelia burgdorferi Group Immunity law medicine Immunology and Allergy Animals Humans Borrelia burgdorferi Lyme Disease Mice Inbred C3H biology Vaccination bacterial infections and mycoses biology.organism_classification medicine.disease Virology Antibodies Bacterial Bacterial vaccine Infectious Diseases Immunization Antigens Surface Bacterial Vaccines Recombinant DNA Female Bacterial Outer Membrane Proteins |
| Zdroj: | The Journal of infectious diseases. 171(5) |
| ISSN: | 0022-1899 |
| Popis: | Although immunization with recombinant outer surface protein A (OspA) appears to protect mice against infection by the agent of Lyme disease, all reported experiments have involved formulations that would not be suitable for use in humans or have not used realistic challenges. This study was designed to determine whether vaccines prepared and used in a phase I human trial, including one currently being used for a phase II trial in sites with endemic Borrelia burgdorferi, conferred protection in the C3H/HeJ mouse model. The challenge was ticks collected from a major site of the trial. None of the vaccinated mice became infected or developed disease, whereas 60% of unvaccinated mice became infected. Spirochetes were destroyed within the guts of virtually all recovered challenge ticks. These preparations of recombinant OspA effectively induced immunity to protect mice from Lyme disease when bitten by ticks collected from a field trial site. |
| Databáze: | OpenAIRE |
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