Effect of dietary oils on the production of n-3 and n-6 metabolites of leukocyte 5-lipoxygenase in five rat strains
| Autor: | W. H. Betts, Michael J. James, Robert A. Gibson, Joanna S. Hawkes, Leslie G. Cleland |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
food.ingredient
Linseed Oil Biophysics Phospholipid Arachidonic Acids In Vitro Techniques Biochemistry Arachidonate Lipoxygenases Leukotriene B4 chemistry.chemical_compound Endocrinology food Fish Oils Linseed oil Animals Plant Oils Sunflower Oil Olive Oil Peritoneal Cavity health care economics and organizations Phospholipids chemistry.chemical_classification Leukotriene Arachidonate 5-Lipoxygenase Arachidonic Acid biology Chemistry Cell Membrane Fatty acid Rats Inbred Strains Fish oil Eicosapentaenoic acid Dietary Fats Rats Eicosapentaenoic Acid Arachidonate 5-lipoxygenase biology.protein lipids (amino acids peptides and proteins) Arachidonic acid Oils |
| Zdroj: | Biochimica et biophysica acta. 1043(3) |
| ISSN: | 0006-3002 |
| Popis: | We examined the influence of various dietary oils, including linseed and fish oil on the relative rates of leukotriene B4 (LTB4) and LTB5 production by rat peritoneal exudate cells in five rat strains. While there was an association between the membrane phospholipid levels of the fatty acid precursors (arachidonic acid (AA) and eicosapentaenoic acid (EPA)) and the rate of synthesis of their respective 5-lipoxygenase products (LTB4 and LTB5), the rate of LTB4 synthesis was a combined function of both AA and EPA levels. We observed a strong linear relationship (correlation coefficient = 0.99) between the ratio of EPA/AA in the cell membrane phospholipids and the ratio of LTB5/LTB4 produced by these cells in vitro; this association was independent of genetic (strain) variability and was independent of the source of EPA (dietary EPA or EPA endogenously synthesized from dietary alpha-linolenic acid). |
| Databáze: | OpenAIRE |
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