A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer
| Autor: | Carlos Stahlhut, Esteban A. Orellana, Kevin Kelnar, Xiaowei Chen, Andrea L. Kasinski, Frank J. Slack, Eliot Shimer, Andreas G. Bader, Sarah Dysart, Jane Zhao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
Lung Neoplasms combinatorial therapeutics Transgene Mice Transgenic Biology medicine.disease_cause Article 03 medical and health sciences Therapeutic approach Mice 0302 clinical medicine Drug Delivery Systems let-7 Carcinoma Non-Small-Cell Lung microRNA Antineoplastic Combined Chemotherapy Protocols Genetics medicine Tumor Cells Cultured Animals Humans Genes Tumor Suppressor Lung cancer Molecular Biology non-small cell lung cancer 030304 developmental biology 0303 health sciences miR-34 Cancer Genetic Therapy medicine.disease Xenograft Model Antitumor Assays 3. Good health Nanostructures Tumor Burden MicroRNAs 030220 oncology & carcinogenesis Immunology Cancer research Non small cell KRAS Lung tissue |
| Zdroj: | Oncogene |
| ISSN: | 1476-5594 0950-9232 |
| Popis: | Targeted cancer therapies, although often effective, have limited utility owing to preexisting primary or acquired secondary resistance. Consequently, agents are sometimes used in combination to simultaneously affect multiple targets. MicroRNA mimics are excellent therapeutic candidates because of their ability to repress multiple oncogenic pathways at once. Here we treated the aggressive Kras;p53 non-small cell lung cancer mouse model and demonstrated efficacy with a combination of two tumor-suppressive microRNAs (miRNAs). Systemic nanodelivery of miR-34 and let-7 suppressed tumor growth leading to survival advantage. This combinatorial miRNA therapeutic approach engages numerous components of tumor cell-addictive pathways and highlights the ability to deliver multiple miRNAs in a safe and effective manner to target lung tissue. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|