Bioelectronic neural pixel: Chemical stimulation and electrical sensing at the same site
| Autor: | Adam Williamson, Amanda Jonsson, Loïg Kergoat, Daniel Simon, Dion Khodagholy, Christophe Bernard, Magnus Berggren, Ilke Uguz, George G. Malliaras, Jonathan Rivnay, Sahika Inal |
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| Přispěvatelé: | Laboratory of Organic Electronics [Norrköping, Sweden] (Department of Science and Technology), Linköping University (LIU), Département Bioélectronique (BEL-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-CMP-GC, Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), ANR-13-BSV5-0019,PolyProbe,Multifunctional implantable probes based on conducting polymer devices(2013), ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011), European Project: 602102,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,EPITARGET(2013), Jirsa, Viktor, Blanc 2013 - Multifunctional implantable probes based on conducting polymer devices - - PolyProbe2013 - ANR-13-BSV5-0019 - Blanc 2013 - VALID, INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE - - Amidex2011 - ANR-11-IDEX-0001 - IDEX - VALID, Targets and biomarkers for antiepileptogenesis - EPITARGET - - EC:FP7:HEALTH2013-11-01 - 2018-10-31 - 602102 - VALID |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Organ Culture Technique Materials science Stimulation Controlled delivery 02 engineering and technology Therapeutic Devices Electrical Engineering Electronic Engineering Information Engineering Feedback regulation gamma-Aminobutyric acid 03 medical and health sciences medicine Premovement neuronal activity Elektroteknik och elektronik Multidisciplinary Epilepsy Organic electronics [SCCO.NEUR]Cognitive science/Neuroscience [SCCO.NEUR] Cognitive science/Neuroscience Inhibitory neurotransmitter 021001 nanoscience & nanotechnology 3. Good health Electrophysiology 030104 developmental biology Therapy 0210 nano-technology Neuroscience Biomedical engineering medicine.drug |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2016, 113 (34), pp.9440-9445. ⟨10.1073/pnas.1604231113⟩ Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (34), pp.9440-9445. ⟨10.1073/pnas.1604231113⟩ |
| ISSN: | 0027-8424 1091-6490 |
| DOI: | 10.1073/pnas.1604231113⟩ |
| Popis: | Local control of neuronal activity is central to many therapeutic strategies aiming to treat neurological disorders. Arguably, the best solution would make use of endogenous highly localized and specialized regulatory mechanisms of neuronal activity, and an ideal therapeutic technology should sense activity and deliver endogenous molecules at the same site for the most efficient feedback regulation. Here, we address this challenge with an organic electronic multifunctional device that is capable of chemical stimulation and electrical sensing at the same site, at the single-cell scale. Conducting polymer electrodes recorded epileptiform discharges induced in mouse hippocampal preparation. The inhibitory neurotransmitter, γ-aminobutyric acid (GABA), was then actively delivered through the recording electrodes via organic electronic ion pump technology. GABA delivery stopped epileptiform activity, recorded simultaneously and colocally. This multifunctional “neural pixel” creates a range of opportunities, including implantable therapeutic devices with automated feedback, where locally recorded signals regulate local release of specific therapeutic agents. Funding agencies:We thank Gaelle Rondeau and the staff of the clean room in Centre Microelectronique de Provence (CMP) for technical support during fabrication. The research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under Grant Agreement 602102 (EPITARGET) and Initiative of Excellence Aix-Marseilles project MIDOE (A_M-AAP-ID-13-24-130531-16.31-BERNARD-HLS). Funding was also provided by the Swedish Innovation Office (2010-00507), the Swedish Research Council (621-2011-3517), and the Knut and Alice Wallenberg Foundation (KAW Scholar, 2012.0302). The authors also thank the National Science Foundation Grant DMR-1105253 for partial support of this work, the French National Research Agency (ANR) through the project PolyProbe (ANR-13-BSV5-0019-01), Fondation pour la Recherche Medicale under Grant Agreements DBS20131128446 and ARF20150934124, Fondation de l'Avenir, the Onnesjo Foundation, the Region Provence-Alpes-Cote d'Azur, and Microvitae Technologies. J.R. and L.K. acknowledge support from Marie Curie Fellowships. The fabrication of the device was performed, in part, at CMP. |
| Databáze: | OpenAIRE |
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