Is sub-mSv CT for evaluation of non-specific findings in bone scintigraphy of oncological patients feasible?
| Autor: | Irina Savitcheva, Albert Sundvall, Seppo Koskinen, Cecilia Wassberg, Yousuf Zakko, Rimma Axelsson, Daniel Thor |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Tomography Emission-Computed Single-Photon medicine.medical_specialty Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Cancer Bone Neoplasms General Medicine Radiation Dosage medicine.disease Multimodal Imaging Bone and Bones Non specific Bone scintigraphy Radiological weapon medicine Feasibility Studies Humans Female Radiology Nuclear Medicine and imaging Radiology Tomography X-Ray Computed business Aged |
| Zdroj: | Acta Radiologica. 61:662-667 |
| ISSN: | 1600-0455 0284-1851 |
| Popis: | Background Hybrid SPECT/CT systems allow the shortening of lead time for investigation of cancer patients, since a complementary CT for radiological characterization of focally increased isotope uptake of unclear origin in bone scintigraphy can be performed simultaneously. The use of low-dose CT (sub-mSv CT) reduces radiation dose compared to standard-dose CT and facilitates the application of complementary CT. Purpose To test the feasibility of sub-mSv CT for the characterization of non-specific findings in the bone scintigraphy of oncological patients. Material and Methods Nineteen oncological patients with a total of 50 findings of unclear origin on bone scintigraphy which required further correlation with morphologic data were included in the study. Each patient underwent two CT scan series consecutively: one low-dose CT and one standard-dose CT. The CT studies were randomized and each finding was rated by four blinded experienced radiologists. A shift in ratings between standard-dose and low-dose images were assessed using the Stuart–Maxwell chi-squared test. Inter-observer agreement and intra-observer agreement was assessed using Light’s kappa and Cohen’s kappa, respectively. Results The mean effective dose of low-dose CT scans was 0.8 mSv compared to 4.2 mSv for the standard-dose CT scans. No statistically significant shift in ratings was observed ( P = 0.62). There was no statistically significant difference in the inter-observer agreements: the values for the standard-dose and low-dose groups were 0.68 (95% confidence interval [CI] 0.57–0.79) and 0.60 (95% CI 0.47–0.72), respectively. Conclusion These results indicate that sub-mSv CT for characterization of non-specific findings in bone scintigraphy of oncological patients is feasible. |
| Databáze: | OpenAIRE |
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