Protective effects of serum thymic factor to Leptospira Interrogans serovar Copenhageni infection in Mongolian gerbils
| Autor: | Masayoshi Yukawa, H. Kobayashi, A. Awaya, Takashi Onodera, Hiroshi Kamata, Toshifumi Kosaka, Koshi Mochizuki |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Thymic Factor Circulating medicine.medical_specialty animal diseases Biology Microbiology Natural killer cell parasitic diseases Leptospiraceae medicine Animals Macrophage Serotyping Cytotoxicity Leptospira interrogans serovar Copenhageni General Veterinary Macrophages General Medicine medicine.disease biology.organism_classification Leptospirosis Killer Cells Natural Disease Models Animal medicine.anatomical_structure Immunology Histopathology sense organs Leptospira interrogans Gerbillinae Weil Disease |
| Zdroj: | Veterinary Microbiology. 41:99-106 |
| ISSN: | 0378-1135 |
| DOI: | 10.1016/0378-1135(94)90139-2 |
| Popis: | The susceptibility to Leptospira interrogans serovar copenhageni in Mongolian gerbils treated with 10 micrograms of serum thymic factor (FTS) 1 day before infection was examined. Susceptibility of gerbils treated 5 times with 10 micrograms of FTS was also investigated. Mortality of FTS-treated gerbils was significantly lower than that of controls when small challenge doses were used. To analyse the FTS-induced resistance to leptospiral infection, natural killer (NK) cell activity and macrophage activity were studied. Macrophage activity was unaltered but NK cell activity was enhanced in FTS-treated gerbils, with or without leptospiral infection. Since no side-effects of FTS were observed, this compound should be considered for the treatment of leptospirosis. |
| Databáze: | OpenAIRE |
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