Lack of biofilm contribution to bacterial colonisation in an experimental model of foreign body infection by Staphylococcus aureus and Staphylococcus epidermidis
| Autor: | Patrice Francois, Friedrich Götz, Patrick Hung Tu Quoc, Sarah E. Cramton, Jacques Schrenzel, Carmelo Bisognano, William L. Kelley, Pierre Vaudaux, Daniel Pablo Lew |
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| Rok vydání: | 2003 |
| Předmět: |
Microbiology (medical)
Staphylococcus aureus Micrococcaceae Staphylococcus epidermidis/ pathogenicity Foreign Bodies/ complications Staphylococcal Infections/ etiology Immunology Guinea Pigs Staphylococcal infections medicine.disease_cause Microbiology Staphylococcus epidermidis In vivo medicine Immunology and Allergy Animals ddc:616 Body fluid biology Biofilm General Medicine Staphylococcal Infections biology.organism_classification medicine.disease Foreign Bodies Disease Models Animal Infectious Diseases Biofilms Staphylococcus aureus/ pathogenicity Bacteria |
| Zdroj: | FEMS Immunology and Medical Microbiology, Vol. 35, No 2 (2003) pp. 135-140 |
| ISSN: | 0928-8244 |
| Popis: | The contribution of in vivo biofilm-forming potential of Staphylococcus aureus and Staphylococcus epidermidis was studied in an experimental model of foreign body infections. Increasing inocula (from 10(2) to 10(7) organisms) of ica-positive strains of S. aureus and S. epidermidis and their ica-negative isogenic mutants (the ica locus codes for a major polysaccharide component of biofilm) were injected into subcutaneously implanted tissue cages in guinea pigs. Surprisingly, bacterial counts and time-course of tissue cage infection by ica-positive strains of S. aureus or S. epidermidis were equivalent to those of their respective ica-negative mutants, in the locally infected fluids and on tissue-cage-inserted plastic coverslips. |
| Databáze: | OpenAIRE |
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