Tuberculosis in HIV-infected infants, children, and adolescents in Latin America
| Autor: | Margot R, Krauss, D Robert, Harris, Thalita, Abreu, Fabiana G, Ferreira, Noris Pavia, Ruz, Carol, Worrell, Rohan, Hazra, George K, Siberry |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Microbiology (medical)
Male Pediatrics medicine.medical_specialty Tuberculosis Latin Americans Adolescent TUBERCULOSE PULMONAR (EPIDEMIOLOGIA) lcsh:QR1-502 Disease lcsh:Microbiology Article lcsh:Infectious and parasitic diseases Young Adult Immune reconstitution inflammatory syndrome Tuberculosis diagnosis Risk Factors medicine Humans lcsh:RC109-216 Prospective Studies Child Tuberculosis Pulmonary Children Retrospective Studies Medicine(all) AIDS-Related Opportunistic Infections business.industry Infant Newborn HIV Infant medicine.disease CD4 Lymphocyte Count Infectious Diseases Latin America Child Preschool Cohort Tuberculosis HIV Female business Contact tracing Cohort study |
| Zdroj: | Brazilian Journal of Infectious Diseases v.19 n.1 2015 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID Brazilian Journal of Infectious Diseases, Volume: 19, Issue: 1, Pages: 23-29, Published: FEB 2015 Brazilian Journal of Infectious Diseases, Vol 19, Iss 1, Pp 23-29 (2015) Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | Objective: To evaluate the occurrence, clinical presentations and diagnostic methods for tuberculosis in a cohort of HIV-infected infants, children and adolescents from Latin America. Methods: A retrospective analysis of children with tuberculosis and HIV was performed within a prospective observational cohort study conducted at multiple clinical sites in Latin America. Results: Of 1114 HIV-infected infants, children, and adolescents followed from 2002 to 2011, 69 that could be classified as having confirmed or presumed tuberculosis were included in this case series; 52.2% (95% CI: 39.8–64.4%) had laboratory-confirmed tuberculosis, 15.9% (95% CI: 8.2–26.7%) had clinically confirmed disease and 31.9% (95% CI: 21.2–44.2%) had presumed tuberculosis. Sixty-six were perinatally HIV-infected. Thirty-two (61.5%) children had a history of contact with an adult tuberculosis case; however information on exposure to active tuberculosis was missing for 17 participants. At the time of tuberculosis diagnosis, 39 were receiving antiretroviral therapy. Sixteen of these cases may have represented immune reconstitution inflammatory syndrome. Conclusions: Our study emphasizes the need for adequate contact tracing of adult tuberculosis cases and screening for HIV or tuberculosis in Latin American children diagnosed with either condition. Preventive strategies in tuberculosis-exposed, HIV-infected children should be optimized. Keywords: Tuberculosis, HIV, Children, Latin America |
| Databáze: | OpenAIRE |
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