Effects of Isometric Handgrip Training in Patients With Peripheral Artery Disease: A Randomized Controlled Trial
| Autor: | Marilia de Almeida Correia, Gabriel Grizzo Cucato, Raphael Mendes Ritti-Dias, Paulo S. L. Oliveira, Daniel J. Green, Breno Quintella Farah, Lauro C. Vianna, Pedro Puech-Leao, Nelson Wolosker |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Brachial Artery Arterial disease Isometric exercise Disease 030204 cardiovascular system & hematology law.invention 03 medical and health sciences Peripheral Arterial Disease 0302 clinical medicine Vascular Stiffness Randomized controlled trial law Exercise Physiology Internal medicine Isometric Contraction medicine Humans In patient Exercise Original Research Aged Hand Strength business.industry Hemodynamics blood pressure 030229 sport sciences intermittent claudication Recovery of Function Middle Aged C600 Intermittent claudication Exercise Therapy Blood pressure Treatment Outcome peripheral vascular disease Cardiology cardiovascular system Female medicine.symptom Cardiology and Cardiovascular Medicine business Brazil |
| Zdroj: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| ISSN: | 2047-9980 |
| Popis: | Background Meta‐analyses have shown that isometric handgrip training ( IHT ) can reduce brachial systolic and diastolic blood pressure ( BP ) by >6/4 mm Hg, respectively. However, whether IHT promotes these effects among patients with peripheral artery disease, who exhibit severe impairment in cardiovascular function, is currently unknown. This study aimed to evaluate the effects of IHT on the cardiovascular function of patients with peripheral artery disease. Methods and Results A randomized controlled trial with peripheral artery disease patients assigned to either the IHT or control group was conducted. The IHT group performed 3 sessions per week, for 8 weeks, of unilateral handgrip exercises, consisting of 4 sets of isometric contractions for 2 minutes at 30% of maximum voluntary contraction and a 4‐minute interval between sets. The control group received a compression ball in order to minimize the placebo effects, representing sham training. The primary outcome was brachial BP . The secondary outcomes were central BP , arterial stiffness parameters, cardiac autonomic modulation, and vascular function. The IHT program reduced diastolic BP (75 [10] mm Hg preintervention versus 72 [11] mm Hg postintervention), with no change in the control group (74 [11] mm Hg preintervention versus 74 [11] mm Hg postintervention), with this between‐group difference being significant ( P =0.04). Flow‐mediated dilation improved in the IHT group (6.0% [5.7] preintervention versus 9.7% [5.5] postintervention), with no change in the control group (7.6% [5.5] preintervention versus 7.4% [5.1] postintervention), with this between‐group difference being significant ( P =0.04). There was no change in other measured variables over the intervention period. Conclusions IHT reduced brachial diastolic BP and improved local vascular function in patients with peripheral artery disease. Clinical Trial Registration URL : https://www.clinicaltrials.gov/ . Unique identifier: NCT 02742220. |
| Databáze: | OpenAIRE |
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