Successful Bosentan and Nonnucleoside Reverse Transcriptase Inhibitor–Based Therapy in a Patient with Acquired Immunodeficiency Syndrome and Pulmonary Arterial Hypertension
| Autor: | Helene Hardy, Harrison W. Farber, Elke S Backman |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Nevirapine
Hypertension Pulmonary HIV Infections Pharmacology Plasma Acquired immunodeficiency syndrome (AIDS) Humans Medicine Drug Interactions Pharmacology (medical) Acquired Immunodeficiency Syndrome Sulfonamides Reverse-transcriptase inhibitor business.industry Endothelin receptor antagonist Bosentan Arteries Middle Aged Viral Load medicine.disease Pulmonary hypertension medicine.anatomical_structure Hypertension Vascular resistance Reverse Transcriptase Inhibitors Female business Viral load medicine.drug |
| Zdroj: | Pharmacotherapy. 30:422-422 |
| ISSN: | 0277-0008 |
| DOI: | 10.1592/phco.30.4.422 |
| Popis: | Pulmonary arterial hypertension (PAH), which can be a complication of human immunodeficiency virus (HIV) infection, is characterized by increased pulmonary arterial pressure and peripheral vascular resistance, subsequently leading to right heart failure. In HIV-infected patients, the management of PAH is challenging given the potential drug interactions between PAH-specific vasodilators and antiretroviral drugs. We describe a 51-year-old female with acquired immunodeficiency syndrome (AIDS) and HIV-associated PAH. She was treated with the oral endothelin receptor antagonist bosentan while taking a nevirapine (a nonnucleoside reverse transcriptase inhibitor)-based antiretroviral regimen. Due to concerns about potential drug interactions with the antiretroviral therapy, her nevirapine plasma concentration, as well as CD4(+) cell count and viral load, were continuously monitored. We observed no interaction between bosentan and nevirapine during a 4-year period. To our knowledge, this report is the first to demonstrate successful, long-term coadministration of bosentan and a nonnucleoside reverse transcriptase inhibitor. |
| Databáze: | OpenAIRE |
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