Cotinine improves visual recognition memory and decreases cortical Tau phosphorylation in the Tg6799 mice
| Autor: | J. Alex Grizzell, George E. Barreto, Sagar Patel, Valentina Echeverria |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Mice Transgenic tau Proteins CREB Nicotine Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Memory Internal medicine medicine Animals Phosphorylation Cotinine Cyclic AMP Response Element-Binding Protein Glycogen synthase Protein kinase B Biological Psychiatry Cerebral Cortex Pharmacology biology Kinase Chemistry Recognition Psychology 030104 developmental biology Endocrinology Visual Perception biology.protein NMDA receptor TBST Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Progress In Neuro-Psychopharmacology & Biological Psychiatry Artículos CONICYT CONICYT Chile instacron:CONICYT |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/j.pnpbp.2017.05.010 |
| Popis: | Alzheimer's disease (AD) is associated with the progressive aggregation of hyperphosphorylated forms of the microtubule associated protein Tau in the central nervous system. Cotinine, the main metabolite of nicotine, reduced working memory deficits, synaptic loss, and amyloid β peptide aggregation into oligomers and plaques as well as inhibited the cerebral Tau kinase, glycogen synthase 3β (GSK3β) in the transgenic (Tg)6799 (5XFAD) mice. In this study, the effect of cotinine on visual recognition memory and cortical Tau phosphorylation at the GSK3β sites Serine (Ser)-396/Ser-404 and phospho-CREB were investigated in the Tg6799 and non-transgenic (NT) littermate mice. Tg mice showed short-term visual recognition memory impairment in the novel object recognition test, and higher levels of Tau phosphorylation when compared to NT mice. Cotinine significantly improved visual recognition memory performance increased CREB phosphorylation and reduced cortical Tau phosphorylation. Potential mechanisms underlying theses beneficial effects are discussed. |
| Databáze: | OpenAIRE |
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