Evaluation of metabolic parameters and aortic elasticity in normotensive children with premature adrenarche
| Autor: | Eylem Topaktaş, Fatma Dursun, Elif Erolu, Heves Kırmızıbekmez |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Adrenal Gland Diseases 030209 endocrinology & metabolism 03 medical and health sciences Vascular Stiffness 0302 clinical medicine Endocrinology Insulin resistance Risk Factors Internal medicine medicine Humans Adrenarche Child Metabolic Syndrome 030219 obstetrics & reproductive medicine business.industry Type 2 Diabetes Mellitus Overweight Atherosclerosis Prognosis medicine.disease Polycystic ovary Case-Control Studies Pediatrics Perinatology and Child Health Cardiology Arterial stiffness Female Aortic stiffness Insulin Resistance Metabolic syndrome business Dyslipidemia Follow-Up Studies |
| Zdroj: | Journal of Pediatric Endocrinology and Metabolism. 34:1009-1015 |
| ISSN: | 2191-0251 0334-018X |
| Popis: | Objectives Premature adrenarche may be associated with an intrauterine programmed metabolic syndrome which should be considered as a warning sign for coronary heart disease due to accelerated atherosclerosis, hypertension, type 2 diabetes mellitus (DM), and polycystic ovary syndrome. Methods Seventy-three patients with premature adrenarche were evaluated for metabolic parameters and aortic elasticity to evaluate the susceptibility to atherosclerosis and compared with a control group. The patients were examined in two groups as overweight and nonoverweight, and metabolic and cardiac parameters were also compared among these groups. Strain, distensibility, and stiffness index parameters were used to evaluate aortic elasticity. Results Biochemical parameters and cardiac measurements were not statistically different between patients and controls. They also did not differ between patients with normal weight and overweight groups. Atherogenic index and insulin resistance were closely related and a positive correlation between cholesterol and triglyceride, and ascending aortic stiffness was found. Conclusions The results may suggest that cholesterol and triglyceride-related arterial involvement is more involved in the pathogenesis of arterial stiffness. It can be considered that ‘being overweight’ or ‘having metabolic profile characterized by insulin resistance and dyslipidemia’ are the major coexisting factors influencing the vascular structure, rather than increased androgens and premature adrenarche itself. |
| Databáze: | OpenAIRE |
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