Further assessment of atrial fibrillation as a risk factor for gastroesophageal reflux disease: a multicenter questionnaire survey
| Autor: | Koichi Akashi, Hideki Shimazu, Gen Nakaji, Satoko Kubota, Keita Odashiro, Toru Maruyama |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Cross-sectional study Gastroenterology Japan Risk Factors Internal medicine Surveys and Questionnaires Atrial Fibrillation Outpatients Internal Medicine medicine Humans Mass Screening Sinus rhythm Risk factor Mass screening Aged Aged 80 and over business.industry Incidence (epidemiology) Incidence Atrial fibrillation General Medicine Middle Aged medicine.disease digestive system diseases Cross-Sectional Studies Cohort GERD Gastroesophageal Reflux Female business |
| Zdroj: | Internal medicine (Tokyo, Japan). 52(21) |
| ISSN: | 1349-7235 |
| Popis: | Although both atrial fibrillation (AF) and gastroesophageal reflux disease (GERD) are common diseases, the relationship between these two conditions remains controversial, depending on the study design and type of AF. Therefore, we focused on the relationship between nonvalvular AF and GERD.A total of 479 consecutive subjects (255 men and 224 women, mean age: 60.4 ± 12.8 years), including outpatients at several hospitals (n=201) and participants of an annual health screening program (n=278), were enrolled. Subjects with valvular AF, malignancy or dementia were excluded. The frequency scale for symptoms of GERD (F-scale) was applied after obtaining each patient's informed consent for screening symptomatic GERD with a total cutoff score of 8 points. The score on the questionnaire was correlated with the baseline characteristics extracted from the patients' medical records.The total F-scale scores were significantly higher in the older patients (≥ 60 years) than in the younger patients (60 years) (p=0.017) and increased in the following order: permanent AFparoxysmal AFsinus rhythm (p=0.003). The incidence of GERD increased in the same order among the patients with the various heart rhythm classifications (p0.001). Coronary heart disease, hypertension, diabetes and dyslipidemia were not correlated with the F-scale scores or incidence of GERD. The stepwise discriminant analyses demonstrated that nonvalvular AF alone was significantly associated with symptomatic GERD (Wilks' lambda=0.983, p=0.004).This multicenter study demonstrated that nonvalvular AF is significantly correlated with symptomatic GERD. This small sample survey warrants a future study of a large-scale cohort. |
| Databáze: | OpenAIRE |
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