Circulatory 25(OH)D and 1,25(OH)2D as differential biomarkers between multiple system atrophy and Parkinson's disease patients

Autor: Shinji Ouma, Yoshio Tsuboi, Takayasu Mishima, Yoichi Matsunaga, Izzettin Hatip-Al-Khatib, Shinsuke Fujioka, Hiromu Ogura, Midori Suenaga, Funda F. Bölükbaşı Hatip
Jazyk: angličtina
Rok vydání: 2021
Předmět:
calcitriol
Parkinson's disease
Youden's J statistic
MMSE
Mini mental state examination
UMSARS
Unified MSA Rating Scale
Gastroenterology
PD
Parkinson's disease
Hoehn & Yahr staging scale
H&Y
Hoehn &Yahr rating scale
middle aged
Updrs iii
Vitamin D
radioimmunoassay
predictive value
vitamin blood level
adult
Healthy subjects
Mini Mental State Examination
Parkinson disease
aged
female
Neurology
Circulatory system
diagnostic accuracy
Original Article
1
25(OH)2D
1
25-dihydroxyvitamin D3 (Calcitriol)
medicine.medical_specialty
MoCA
Montreal Cognitive Assessment
MSA
Multiple system atrophy
25(OH)D
25-hydroxyvitamin D3
area under the curve
sex difference
vitamin D deficiency
Article
Atrophy
male
demographics
Internal medicine
medicine
Vitamin D and neurology
Unified PD rating scale
controlled study
human
RC346-429
business.industry
Unified MSA rating scale
clinical assessment
Multiple system atrophy
medicine.disease
major clinical study
25 hydroxyvitamin D
Unified Parkinson Disease Rating Scale
sensitivity and specificity
Shy Drager syndrome
UPDRS
Unified PD Rating Scale
Neurology. Diseases of the nervous system
disease duration
business
rating scale
Zdroj: eNeurologicalSci
eNeurologicalSci, Vol 25, Iss, Pp 100369-(2021)
ISSN: 2405-6502
Popis: Background and purpose There is sufficient evidence to support vitamin D's noncalcemic effects and the role of vitamin D deficiency in the development of a wide range of neurological disorders. This study aimed to evaluate whether serum 25(OH)D and 1,25(OH) 2 D could be used as biomarkers to differentiate between healthy subjects (HS), multiple system atrophy (MSA) and Parkinson's disease (PD) patients of both genders. Methods A total of 107 subjects were included in this study, divided into three groups: 1- HS (n = 61), 2- MSA patients (n = 19), and 3- PD patients (n = 27). The patients were assessed using UMSARS II, UPDRS III, H&Y, MMSE and MoCA rating scales. The levels of 25(OH)D and 1,25(OH) 2 D in serum were determined using the radioimmunoassay technique. Results The levels of 25(OH)D and 1,25(OH) 2 D in HS were 26.85 +/− 7.62 ng/mL and 53.63 +/− 13.66 pg/mL respectively. 25(OH)D levels were lower in both MSA and PD by 61% and 50%, respectively (P = 0.0001 vs. HS). 1,25(OH) 2 D levels were lower in MSA by 29%(P = 0.001 vs HS). There was a correlation between 25(OH)D and 1,25(OH) 2 D in MSA and PD, but not in HS. 1,25(OH) 2 D regressed with MMSE (β = 0.476, P = 0.04, R 2 = 0.226) in MSA, and with UPDRS III (β = −0.432, P = 0.024, R 2 = 0.187) and MoCA (β = 0.582, P = 0.005,R 2 = 0.279) in PD. 25(OH)D displayed considerable differentiative strength between HS and MSA (Wald = 17.123, OR = 0.586, P = 0.0001; AUC = 0.982, sensitivity and Youden index = 0.882, P = 0.0001) and PD (Wald = 18.552, OR = 0.700, P = 0.0001; AUC = 0.943, sensitivity = 0.889, YI = 0.791, P = 0.0001). 1,25(OH) 2 D distinguished MSA from PD (Wald 16.178, OR = 1.117, P = 0.0001; AUC = 0.868, sensitivity = 0.926, Youden index =0.632, P = 0.0001). H&Y exhibited the highest sensitivity, AUC, and significant distinguishing power between MSA and PD. Conclusions Serum 25(OH)D and 1,25(OH) 2 D could be useful biomarkers for MSA and PD. 25(OH)D and H&Y provided the highest sensitivity and group classification characteristics.
Highlights • Low serum 1,25(OH)2D and 25(OH)D concentrations in MSA, whereas only low 25(OH)D in PD. • The decrement of serum 1,25(OH)2D concentration is higher in MSA than in PD. • In MSA, 25(OH)D correlate with 1,25(OH)2D, UMSARS and H&Y. • In PD, 25(OH)D correlate with 1,25(OH)2D and H&Y. • 25(OH)D and H&Y display the highest diagnostic performance as binary classifier for PD and MSA.
Databáze: OpenAIRE
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