Platelet high affinity adrenoceptor binding sites labelled with the agonist [3H]UK-14,304, in depressed patients and matched controls
| Autor: | Cornelius Katona, Eugene S. Paykel, Andreas E. Theodorou, Anthony S. Hale, J.S. Kelly, Roger W. Horton, Sharon L. Davies, Yukiharu Yamaguchi |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Blood Platelets Male Agonist medicine.medical_specialty Adrenergic receptor medicine.drug_class Clonidine Quinoxalines Internal medicine medicine Radioligand Humans Platelet Binding site Pharmacology α2 adrenergic receptor Depression Chemistry Antagonist Middle Aged Receptors Adrenergic alpha Kinetics Endocrinology Brimonidine Tartrate Female medicine.drug |
| Zdroj: | European Journal of Pharmacology. 126:329-332 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(86)90067-1 |
| Popis: | Increased number of platelet high affinity α 2 -adrenoceptors binding sites have been reported in depressed patients using the agonist radioligand [ 3 H]clonidine, whereas no differences from controls have been found using antagonist radioligands. We have measured platelet high affinity α 2 -adrenoceptors in 13 depressed patients and 14 well-matched controls using a new selective agonist radioligand, [ 3 H]UK-14,304. Unlike previous studies using [ 3 H]clonidine, we find no differences in B max or K D of the high affinity α 2 -adrenoceptor binding sites between the 2 groups. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|